| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | BRCA2 | Thr207 | TPPTLSStVLIVRNE | phosphorylation unknown | 12815053 | SIGNOR-249221 |
| PLK1 | BRCA2 | Thr207 | TPPTLSStVLIVRNE | phosphorylation down-regulates activity | 12815053 | SIGNOR-102502 |
| PLK1 | BRCA2 | Ser193 | AEVDPDMsWSSSLAT | phosphorylation unknown | 12815053 | SIGNOR-249217 |
| PLK1 | BRCA2 | Ser193 | AEVDPDMsWSSSLAT | phosphorylation down-regulates activity | 12815053 | SIGNOR-102486 |
| PLK1 | BRCA2 | Ser206 | ATPPTLSsTVLIVRN | phosphorylation unknown | 12815053 | SIGNOR-249219 |
| PLK1 | BRCA2 | Ser206 | ATPPTLSsTVLIVRN | phosphorylation down-regulates activity | 12815053 | SIGNOR-102494 |
| PLK1 | BRCA2 | Thr203 | SSLATPPtLSSTVLI | phosphorylation unknown | 12815053 | SIGNOR-249220 |
| PLK1 | BRCA2 | Ser205 | LATPPTLsSTVLIVR | phosphorylation unknown | 12815053 | SIGNOR-249218 |
| PLK1 | BRCA2 | Ser205 | LATPPTLsSTVLIVR | phosphorylation down-regulates activity | 12815053 | SIGNOR-102490 |
| PLK1 | BRCA2 | Thr203 | SSLATPPtLSSTVLI | phosphorylation down-regulates activity | 12815053 | SIGNOR-102498 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr207 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249221 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr207 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102502 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer193 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249217 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer193 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102486 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer206 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249219 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer206 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102494 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr203 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249220 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer205 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249218 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer205 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102490 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PThr203 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102498 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249221 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102502 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249217 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102486 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249219 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102494 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249220 |
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249218 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102490 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102498 |
