| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | BRCA2 | Ser193 | AEVDPDMsWSSSLAT | phosphorylation unknown | 12815053 | SIGNOR-249217 |
| PLK1 | BRCA2 | Ser193 | AEVDPDMsWSSSLAT | phosphorylation down-regulates activity | 12815053 | SIGNOR-102486 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer193 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-249217 |
| PLK1 | phosphorylation up-regulates → | BRCA2 PSer193 | phosphorylation down-regulates ⊣ | BRCA2 | 12815053 | SIGNOR-102486 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → unknown | BRCA2 | SIGNOR-249217 |
| PLK1 | phosphorylation → down-regulates activity | BRCA2 | SIGNOR-102486 |
