| Name | IRAK1 |
| ID | P51617 |
| Role | kinase |
| Enzymatic Domains |
Death 27-106
Protein kinase 212-521 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 15465816 | SIGNOR-129685 |
| IRAK1 | IRAK1 | Ser376 | GSSPSQSsMVARTQT | phosphorylation up-regulates activity | 11960013 | SIGNOR-251326 |
| IRAK1 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 11960013 | SIGNOR-251330 |
| IRAK1 | IRAK1 | Thr66 | CERSGQRtASVLWPW | phosphorylation up-regulates activity | 12138165 | SIGNOR-251327 |
| IRAK1 | IRAK1 | Thr209 | LCEISRGtHNFSEEL | phosphorylation up-regulates activity | 14625308 | SIGNOR-119212 |
| IRAK1 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 14625308 | SIGNOR-119216 |
| IRAK1 | PELI3 | – | phosphorylation up-regulates | 12874243 | SIGNOR-103983 | |
| IRAK1 | PELI3 | – | phosphorylation up-regulates | 17997719 | SIGNOR-159052 | |
| IRAK1 | IRF7 | – | phosphorylation up-regulates activity | 15767370 | SIGNOR-278235 | |
| IRAK1 | PELI1 | Ser293 | FNTLAFPsMKRKDVV | phosphorylation up-regulates activity | 12496252 | SIGNOR-96735 |
| IRAK1 | PELI1 | Ser76 | ISNKDQHsISYTLSR | phosphorylation up-regulates activity | 12496252 | SIGNOR-96739 |
| IRAK1 | PELI1 | Ser78 | NKDQHSIsYTLSRAQ | phosphorylation up-regulates activity | 12496252 | SIGNOR-96743 |
| IRAK1 | PELI1 | Ser82 | HSISYTLsRAQTVVV | phosphorylation up-regulates activity | 12496252 | SIGNOR-96747 |
| IRAK1 | PELI1 | Thr288 | QCPVGFNtLAFPSMK | phosphorylation up-regulates activity | 12496252 | SIGNOR-96751 |
| IRAK1 | PELI1 | Thr86 | YTLSRAQtVVVEYTH | phosphorylation up-regulates activity | 12496252 | SIGNOR-96759 |
| IRAK1 | PELI1 | Ser293 | FNTLAFPsMKRKDVV | phosphorylation up-regulates activity | 19264966 | SIGNOR-276137 |
| IRAK1 | PELI1 | Ser76 | ISNKDQHsISYTLSR | phosphorylation up-regulates activity | 19264966 | SIGNOR-276134 |
| IRAK1 | PELI1 | Ser78 | NKDQHSIsYTLSRAQ | phosphorylation up-regulates activity | 19264966 | SIGNOR-276133 |
| IRAK1 | PELI1 | Ser82 | HSISYTLsRAQTVVV | phosphorylation up-regulates activity | 19264966 | SIGNOR-276139 |
| IRAK1 | PELI1 | Thr288 | QCPVGFNtLAFPSMK | phosphorylation up-regulates activity | 19264966 | SIGNOR-276136 |
| IRAK1 | PELI1 | Thr80 | DQHSISYtLSRAQTV | phosphorylation up-regulates activity | 19264966 | SIGNOR-276138 |
| IRAK1 | PELI1 | Thr86 | YTLSRAQtVVVEYTH | phosphorylation up-regulates activity | 19264966 | SIGNOR-276135 |
| IRAK1 | GLIPR2 | Ser58 | ILKHSPEsSRGQCGE | phosphorylation up-regulates activity | 25544559 | SIGNOR-262887 |
| IRAK1 | PELI2 | – | phosphorylation up-regulates activity | 12860405 | SIGNOR-278947 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 15465816 | SIGNOR-129685 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PSer376 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251326 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251330 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr66 | phosphorylation up-regulates → | IRAK1 | 12138165 | SIGNOR-251327 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr209 | phosphorylation up-regulates → | IRAK1 | 14625308 | SIGNOR-119212 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 14625308 | SIGNOR-119216 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer293 | phosphorylation up-regulates → | PELI1 | 12496252 | SIGNOR-96735 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer76 | phosphorylation up-regulates → | PELI1 | 12496252 | SIGNOR-96739 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer78 | phosphorylation up-regulates → | PELI1 | 12496252 | SIGNOR-96743 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer82 | phosphorylation up-regulates → | PELI1 | 12496252 | SIGNOR-96747 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PThr288 | phosphorylation up-regulates → | PELI1 | 12496252 | SIGNOR-96751 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PThr86 | phosphorylation up-regulates → | PELI1 | 12496252 | SIGNOR-96759 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer293 | phosphorylation up-regulates → | PELI1 | 19264966 | SIGNOR-276137 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer76 | phosphorylation up-regulates → | PELI1 | 19264966 | SIGNOR-276134 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer78 | phosphorylation up-regulates → | PELI1 | 19264966 | SIGNOR-276133 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PSer82 | phosphorylation up-regulates → | PELI1 | 19264966 | SIGNOR-276139 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PThr288 | phosphorylation up-regulates → | PELI1 | 19264966 | SIGNOR-276136 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PThr80 | phosphorylation up-regulates → | PELI1 | 19264966 | SIGNOR-276138 |
| IRAK1 | phosphorylation up-regulates → | PELI1 PThr86 | phosphorylation up-regulates → | PELI1 | 19264966 | SIGNOR-276135 |
| IRAK1 | phosphorylation up-regulates → | GLIPR2 PSer58 | phosphorylation up-regulates → | GLIPR2 | 25544559 | SIGNOR-262887 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IRAK1 | phosphorylation → up-regulates | STAT3 | SIGNOR-129685 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251326 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251330 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251327 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-119212 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-119216 |
| IRAK1 | phosphorylation → up-regulates | PELI3 | SIGNOR-103983 |
| IRAK1 | phosphorylation → up-regulates | PELI3 | SIGNOR-159052 |
| IRAK1 | phosphorylation → up-regulates activity | IRF7 | SIGNOR-278235 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-96735 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-96739 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-96743 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-96747 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-96751 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-96759 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-276137 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-276134 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-276133 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-276139 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-276136 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-276138 |
| IRAK1 | phosphorylation → up-regulates activity | PELI1 | SIGNOR-276135 |
| IRAK1 | phosphorylation → up-regulates activity | GLIPR2 | SIGNOR-262887 |
| IRAK1 | phosphorylation → up-regulates activity | PELI2 | SIGNOR-278947 |