| Name | IRAK1 |
| ID | P51617 |
| Role | substrate |
| Enzymatic Domains |
Death 27-106
Protein kinase 212-521 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | IRAK1 | Thr100 | LRARDIItAWHPPAP | phosphorylation down-regulates activity | 11976320 | SIGNOR-248008 |
| IRAK1 | IRAK1 | Ser376 | GSSPSQSsMVARTQT | phosphorylation up-regulates activity | 11960013 | SIGNOR-251326 |
| IRAK4 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 11960013 | SIGNOR-251329 |
| IRAK1 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 14625308 | SIGNOR-119216 |
| IRAK4 | IRAK1 | – | phosphorylation up-regulates activity | 17337443 | SIGNOR-153458 | |
| IRAK4 | IRAK1 | – | phosphorylation up-regulates activity | 11960013 | SIGNOR-117315 | |
| IRAK4 | IRAK1 | Ser376 | GSSPSQSsMVARTQT | phosphorylation up-regulates activity | 11960013 | SIGNOR-251328 |
| IRAK1 | IRAK1 | Thr209 | LCEISRGtHNFSEEL | phosphorylation up-regulates activity | 14625308 | SIGNOR-119212 |
| IRAK1 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 11960013 | SIGNOR-251330 |
| IRAK1 | IRAK1 | Thr66 | CERSGQRtASVLWPW | phosphorylation up-regulates activity | 12138165 | SIGNOR-251327 |
| AKT1 | IRAK1 | Thr100 | LRARDIItAWHPPAP | phosphorylation down-regulates activity | 11976320 | SIGNOR-252551 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | IRAK1 PThr100 | phosphorylation down-regulates ⊣ | IRAK1 | 11976320 | SIGNOR-248008 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PSer376 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251326 |
| IRAK4 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251329 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 14625308 | SIGNOR-119216 |
| IRAK4 | phosphorylation up-regulates → | IRAK1 PSer376 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251328 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr209 | phosphorylation up-regulates → | IRAK1 | 14625308 | SIGNOR-119212 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251330 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr66 | phosphorylation up-regulates → | IRAK1 | 12138165 | SIGNOR-251327 |
| AKT1 | phosphorylation up-regulates → | IRAK1 PThr100 | phosphorylation down-regulates ⊣ | IRAK1 | 11976320 | SIGNOR-252551 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | IRAK1 | SIGNOR-248008 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251326 |
| IRAK4 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251329 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-119216 |
| IRAK4 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-153458 |
| IRAK4 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-117315 |
| IRAK4 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251328 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-119212 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251330 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251327 |
| AKT1 | phosphorylation → down-regulates activity | IRAK1 | SIGNOR-252551 |