| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | IRAK1 | Thr100 | LRARDIItAWHPPAP | phosphorylation down-regulates activity | 11976320 | SIGNOR-248008 |
| AKT1 | IRAK1 | Thr100 | LRARDIItAWHPPAP | phosphorylation down-regulates activity | 11976320 | SIGNOR-252551 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | IRAK1 PThr100 | phosphorylation down-regulates ⊣ | IRAK1 | 11976320 | SIGNOR-248008 |
| AKT1 | phosphorylation up-regulates → | IRAK1 PThr100 | phosphorylation down-regulates ⊣ | IRAK1 | 11976320 | SIGNOR-252551 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | IRAK1 | SIGNOR-248008 |
| AKT1 | phosphorylation → down-regulates activity | IRAK1 | SIGNOR-252551 |