| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK1 | IRAK1 | Ser376 | GSSPSQSsMVARTQT | phosphorylation up-regulates activity | 11960013 | SIGNOR-251326 |
| IRAK4 | IRAK1 | Ser376 | GSSPSQSsMVARTQT | phosphorylation up-regulates activity | 11960013 | SIGNOR-251328 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK1 | phosphorylation up-regulates → | IRAK1 PSer376 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251326 |
| IRAK4 | phosphorylation up-regulates → | IRAK1 PSer376 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251328 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251326 |
| IRAK4 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251328 |