| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK1 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 14625308 | SIGNOR-119216 |
| IRAK4 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 11960013 | SIGNOR-251329 |
| IRAK1 | IRAK1 | Thr387 | RTQTVRGtLAYLPEE | phosphorylation up-regulates activity | 11960013 | SIGNOR-251330 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 14625308 | SIGNOR-119216 |
| IRAK4 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251329 |
| IRAK1 | phosphorylation up-regulates → | IRAK1 PThr387 | phosphorylation up-regulates → | IRAK1 | 11960013 | SIGNOR-251330 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-119216 |
| IRAK4 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251329 |
| IRAK1 | phosphorylation → up-regulates activity | IRAK1 | SIGNOR-251330 |