Entity Details

Name CCR5
ID P51681
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GRK3CCR5Ser349
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STGEQEIsVGLphosphorylation
down-regulates activity		10085131SIGNOR-249679
GRK3CCR5Ser336QEAPERAsSVYTRSTphosphorylation
down-regulates activity		10085131SIGNOR-251463
GRK3CCR5Ser337
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EAPERASsVYTRSTGphosphorylation
down-regulates activity		10085131SIGNOR-251464
GRK3CCR5Ser342ASSVYTRsTGEQEISphosphorylation
down-regulates activity		10085131SIGNOR-249675
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GRK3phosphorylation
up-regulates
→
CCR5
PSer349		phosphorylation
down-regulates
⊣		CCR510085131SIGNOR-249679
GRK3phosphorylation
up-regulates
→
CCR5
PSer336		phosphorylation
down-regulates
⊣		CCR510085131SIGNOR-251463
GRK3phosphorylation
up-regulates
→
CCR5
PSer337		phosphorylation
down-regulates
⊣		CCR510085131SIGNOR-251464
GRK3phosphorylation
up-regulates
→
CCR5
PSer342		phosphorylation
down-regulates
⊣		CCR510085131SIGNOR-249675
Regulator Mechanism/Effect Target SIGNOR-ID
GRK3phosphorylation
→
down-regulates activity 		CCR5SIGNOR-249679
GRK3phosphorylation
→
down-regulates activity 		CCR5SIGNOR-251463
GRK3phosphorylation
→
down-regulates activity 		CCR5SIGNOR-251464
GRK3phosphorylation
→
down-regulates activity 		CCR5SIGNOR-249675