| Name | STAT5B |
| ID | P51692 |
| Role | substrate |
| Enzymatic Domains |
SH2 589-686 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | STAT5B | – | phosphorylation up-regulates | 9575217 | SIGNOR-56894 | |
| EPHA4 | STAT5B | – | phosphorylation up-regulates activity | 28686668 | SIGNOR-278934 | |
| PTK6 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | phosphorylation up-regulates | 17997837 | SIGNOR-159066 |
| EGFR | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 11751923 | SIGNOR-251098 |
| PTPN1 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | dephosphorylation down-regulates activity | 10993888 | SIGNOR-248429 |
| EGFR | STAT5B | Tyr740 | AVCPQAHyNMYPQNP | phosphorylation up-regulates | 11751923 | SIGNOR-113397 |
| LCK | STAT5B | – | phosphorylation up-regulates activity | 16446405 | SIGNOR-279056 | |
| EGFR | STAT5B | Tyr725 | AGGGSATyMDQAPSP | phosphorylation up-regulates | 11751923 | SIGNOR-113393 |
| PTPN1 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | dephosphorylation down-regulates | 10993888 | SIGNOR-82042 |
| SRC | STAT5B | Tyr679 | DRPKDEVySKYYTPV | phosphorylation up-regulates | 12621061 | SIGNOR-99002 |
| PTPN2 | STAT5B | – | dephosphorylation down-regulates activity | 12359225 | SIGNOR-277126 | |
| EGFR | STAT5B | Tyr743 | PQAHYNMyPQNPDSV | phosphorylation up-regulates | 11751923 | SIGNOR-113401 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK6 | phosphorylation up-regulates → | STAT5B PTyr699 | phosphorylation up-regulates → | STAT5B | 17997837 | SIGNOR-159066 |
| EGFR | phosphorylation up-regulates → | STAT5B PTyr699 | phosphorylation up-regulates → | STAT5B | 11751923 | SIGNOR-251098 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5B PTyr699 | dephosphorylation up-regulates → | STAT5B | 10993888 | SIGNOR-248429 |
| EGFR | phosphorylation up-regulates → | STAT5B PTyr740 | phosphorylation up-regulates → | STAT5B | 11751923 | SIGNOR-113397 |
| EGFR | phosphorylation up-regulates → | STAT5B PTyr725 | phosphorylation up-regulates → | STAT5B | 11751923 | SIGNOR-113393 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5B PTyr699 | dephosphorylation up-regulates → | STAT5B | 10993888 | SIGNOR-82042 |
| SRC | phosphorylation up-regulates → | STAT5B PTyr679 | phosphorylation up-regulates → | STAT5B | 12621061 | SIGNOR-99002 |
| EGFR | phosphorylation up-regulates → | STAT5B PTyr743 | phosphorylation up-regulates → | STAT5B | 11751923 | SIGNOR-113401 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation → up-regulates | STAT5B | SIGNOR-56894 |
| EPHA4 | phosphorylation → up-regulates activity | STAT5B | SIGNOR-278934 |
| PTK6 | phosphorylation → up-regulates | STAT5B | SIGNOR-159066 |
| EGFR | phosphorylation → up-regulates activity | STAT5B | SIGNOR-251098 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT5B | SIGNOR-248429 |
| EGFR | phosphorylation → up-regulates | STAT5B | SIGNOR-113397 |
| LCK | phosphorylation → up-regulates activity | STAT5B | SIGNOR-279056 |
| EGFR | phosphorylation → up-regulates | STAT5B | SIGNOR-113393 |
| PTPN1 | dephosphorylation down-regulates | STAT5B | SIGNOR-82042 |
| SRC | phosphorylation → up-regulates | STAT5B | SIGNOR-99002 |
| PTPN2 | dephosphorylation → down-regulates activity | STAT5B | SIGNOR-277126 |
| EGFR | phosphorylation → up-regulates | STAT5B | SIGNOR-113401 |