| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | phosphorylation up-regulates activity | 11751923 | SIGNOR-251098 |
| PTK6 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | phosphorylation up-regulates | 17997837 | SIGNOR-159066 |
| PTPN1 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | dephosphorylation down-regulates | 10993888 | SIGNOR-82042 |
| PTPN1 | STAT5B | Tyr699 | TAKAVDGyVKPQIKQ | dephosphorylation down-regulates activity | 10993888 | SIGNOR-248429 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | STAT5B PTyr699 | phosphorylation up-regulates → | STAT5B | 11751923 | SIGNOR-251098 |
| PTK6 | phosphorylation up-regulates → | STAT5B PTyr699 | phosphorylation up-regulates → | STAT5B | 17997837 | SIGNOR-159066 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5B PTyr699 | dephosphorylation up-regulates → | STAT5B | 10993888 | SIGNOR-82042 |
| PTPN1 | dephosphorylation down-regulates ⊣ | STAT5B PTyr699 | dephosphorylation up-regulates → | STAT5B | 10993888 | SIGNOR-248429 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates activity | STAT5B | SIGNOR-251098 |
| PTK6 | phosphorylation → up-regulates | STAT5B | SIGNOR-159066 |
| PTPN1 | dephosphorylation down-regulates | STAT5B | SIGNOR-82042 |
| PTPN1 | dephosphorylation → down-regulates activity | STAT5B | SIGNOR-248429 |
