Entity Details

Name RPS6KA3
ID P51812
Role kinase
Enzymatic Domains
Protein kinase 1 68-327
PROSITE-ProRule
AGC-kinase C-terminal 328-397
PROSITE-ProRule
Protein kinase 2 422-679
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
RPS6KA3H3C1Ser11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
15994958SIGNOR-138475
RPS6KA3PFKFB2Ser466PVRMRRNsFTPLSSSphosphorylation
up-regulates activity
9211863SIGNOR-49367
RPS6KA3NR4A1Ser351GRRGRLPsKPKQPPDphosphorylation
unknown
16223362SIGNOR-249295
RPS6KA3ATF1phosphorylation
up-regulates activity
10723128SIGNOR-280117
RPS6KA3ATMSer1981SLAFEEGsQSTTISSphosphorylation
up-regulates activity
24086335SIGNOR-280118
RPS6KA3SLC9A1Ser703MSRARIGsDPLAYEPphosphorylation
up-regulates activity
30377223SIGNOR-280119
RPS6KA3H2BC3Ser33DGKKRKRsRKESYSIphosphorylation
unknown
21646345SIGNOR-174026
RPS6KA3CREB1Ser119EILSRRPsYRKILNDphosphorylation
up-regulates activity
8688081SIGNOR-248951
RPS6KA3TP53Ser15PSVEPPLsQETFSDLphosphorylation
up-regulates activity
15867353SIGNOR-279567
RPS6KA3CASP8Thr263SIRDRNGtHLDAGALphosphorylation
down-regulates quantity by destabilization
21183680SIGNOR-272997
RPS6KA3ESR1Ser167GGRERLAsTNDKGSMphosphorylation
up-regulates
19112174SIGNOR-182958
RPS6KA3MAP3K5Thr1326VNGADEDtISRFLAEphosphorylation
down-regulates activity
23608533SIGNOR-276462
RPS6KA3VGLL1Ser84PNQWRYSsPWTKPQPphosphorylation
down-regulates activity
33069758SIGNOR-273842
RPS6KA3NFATC4Ser289PALSRRGsLGEEGSEphosphorylation
up-regulates
17213202SIGNOR-234473
RPS6KA3CICSer173PGKRRTQsLSALPKEphosphorylation
down-regulates
21087211SIGNOR-169887
RPS6KA3HMGN2Ser25KDEPQRRsARLSAKPphosphorylation
down-regulates activity
11438671SIGNOR-249102
RPS6KA3FOXN2Ser369 LGDSGYAsQPCAKISphosphorylation
down-regulates quantity by destabilization
29396548SIGNOR-273841
RPS6KA3Histone H3phosphorylation
down-regulates activity
10464286SIGNOR-265347
RPS6KA3NFATC4Ser281SGTPSSAsPALSRRGphosphorylation
up-regulates
17213202SIGNOR-234465
RPS6KA3H2AXSer140GKKATQAsQEYphosphorylation
up-regulates activity
21224359SIGNOR-279349
RPS6KA3H2AXSer17 KARAKAKsRSSRAGLphosphorylation
up-regulates activity
21224359SIGNOR-279350
RPS6KA3H3C1Ser11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
14625384SIGNOR-119229
RPS6KA3THSer40GQGAPGPsLTGSPWPphosphorylation
up-regulates
12421349SIGNOR-95483
RPS6KA3KRT18Ser53ISVSRSTsFRGGMGSphosphorylation
unknown
7523419SIGNOR-248895
RPS6KA3NFATC4Ser676SNGRRKRsPTQSFRFphosphorylation
up-regulates
15657420SIGNOR-133283
RPS6KA3TINF2Ser295FPFRNLGsPTQVISKphosphorylation
unknown
23977114SIGNOR-202532
RPS6KA3YBX1Ser102NPRKYLRsVGDGETVphosphorylation
up-regulates
19036157SIGNOR-182165
RPS6KA3PFKFB2Ser466PVRMRRNsFTPLSSSphosphorylation
up-regulates activity
2846551SIGNOR-23753
RPS6KA3H3-3ASer11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
15994958SIGNOR-138471
RPS6KA3HMGN1Ser7sSAEGAAKphosphorylation
unknown
12773393SIGNOR-249215
RPS6KA3RANBP3Ser57HGTGHPEsAGEHALEphosphorylation
up-regulates quantity
18280241SIGNOR-276148
RPS6KA3H3C1Ser11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
10464286SIGNOR-70436
RPS6KA3MAP3K5Thr1109DRKIIATtLSKLKLEphosphorylation
down-regulates activity
23608533SIGNOR-276463
RPS6KA3TRAF6Ser46TASTGNLsSSFMEEIphosphorylation
up-regulates activity
29563609SIGNOR-278302
RPS6KA3FGFR1Ser789DTRSSTCsSGEDSVFphosphorylation
down-regulates quantity
24141780SIGNOR-276599
RPS6KA3NFATC4Ser344QAVALPRsEEPASCNphosphorylation
up-regulates
17213202SIGNOR-235652
RPS6KA3HMGN1Ser21 KEEPKRRsARLSAKPphosphorylation
down-regulates activity
11438671SIGNOR-249100
RPS6KA3H3-3ASer11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
14625384SIGNOR-119225
RPS6KA3TINF2Ser330ASTGKSKsPCQTLGGphosphorylation
unknown
23977114SIGNOR-202536
RPS6KA3HMGN2Ser29QRRSARLsAKPAPPKphosphorylation
down-regulates activity
11438671SIGNOR-249103
RPS6KA3NFATC4Ser285SSASPALsRRGSLGEphosphorylation
up-regulates
17213202SIGNOR-234469
RPS6KA3THSer40GQGAPGPsLTGSPWPphosphorylation
up-regulates
7901013SIGNOR-34682
RPS6KA3EIF2AK2Thr451KRTRSKGtLRYMSPEphosphorylation
up-regulates
17404396SIGNOR-154183
RPS6KA3FOXN2Ser365EDDPLGDsGYASQPCphosphorylation
down-regulates quantity by destabilization
29396548SIGNOR-273840
RPS6KA3H3-3ASer11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
10464286SIGNOR-70432
RPS6KA3THSer71RFIGRRQsLIEDARKphosphorylation
up-regulates
7901013SIGNOR-34686
RPS6KA3HMGN1Ser25KRRSARLsAKPPAKVphosphorylation
down-regulates activity
11438671SIGNOR-249101
RPS6KA3MAP3K5Ser83ATRGRGSsVGGGSRRphosphorylation
down-regulates activity
23608533SIGNOR-276464
RPS6KA3NFKBIASer32LLDDRHDsGLDSMKDphosphorylation
down-regulates quantity by destabilization
20385620SIGNOR-279108
RPS6KA3WWC1Thr929STIIRSKtFSPGPQSphosphorylation
up-regulates
24269383SIGNOR-203306
RPS6KA3GSK3ASer21 SGRARTSsFAEPGGGphosphorylation
down-regulates activity
11583116SIGNOR-110827
RPS6KA3THSer71RFIGRRQsLIEDARKphosphorylation
up-regulates
12421349SIGNOR-95487
RPS6KA3KCNK3Ser393GLMKRRSsVphosphorylation
up-regulates activity
21357689SIGNOR-172470
RPS6KA3WWC1Ser947CRLNRSDsDSSTLSKphosphorylation
up-regulates
24269383SIGNOR-203302
RPS6KA3BADSer75EIRSRHSsYPAGTEDphosphorylation
down-regulates
19282669SIGNOR-184595
RPS6KA3ATF4Ser245TRGSPNRsLPSPGVLphosphorylation
up-regulates
15109498SIGNOR-124436
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
RPS6KA3phosphorylation
up-regulates
H3C1
PSer11
phosphorylation
down-regulates
H3C115994958SIGNOR-138475
RPS6KA3phosphorylation
up-regulates
PFKFB2
PSer466
phosphorylation
up-regulates
PFKFB29211863SIGNOR-49367
RPS6KA3phosphorylation
up-regulates
NR4A1
PSer351
phosphorylation
down-regulates
NR4A116223362SIGNOR-249295
RPS6KA3phosphorylation
up-regulates
ATM
PSer1981
phosphorylation
up-regulates
ATM24086335SIGNOR-280118
RPS6KA3phosphorylation
up-regulates
SLC9A1
PSer703
phosphorylation
up-regulates
SLC9A130377223SIGNOR-280119
RPS6KA3phosphorylation
up-regulates
H2BC3
PSer33
phosphorylation
down-regulates
H2BC321646345SIGNOR-174026
RPS6KA3phosphorylation
up-regulates
CREB1
PSer119
phosphorylation
up-regulates
CREB18688081SIGNOR-248951
RPS6KA3phosphorylation
up-regulates
TP53
PSer15
phosphorylation
up-regulates
TP5315867353SIGNOR-279567
RPS6KA3phosphorylation
up-regulates
CASP8
PThr263
phosphorylation
down-regulates
CASP821183680SIGNOR-272997
RPS6KA3phosphorylation
up-regulates
ESR1
PSer167
phosphorylation
up-regulates
ESR119112174SIGNOR-182958
RPS6KA3phosphorylation
up-regulates
MAP3K5
PThr1326
phosphorylation
down-regulates
MAP3K523608533SIGNOR-276462
RPS6KA3phosphorylation
up-regulates
VGLL1
PSer84
phosphorylation
down-regulates
VGLL133069758SIGNOR-273842
RPS6KA3phosphorylation
up-regulates
NFATC4
PSer289
phosphorylation
up-regulates
NFATC417213202SIGNOR-234473
RPS6KA3phosphorylation
up-regulates
CIC
PSer173
phosphorylation
down-regulates
CIC21087211SIGNOR-169887
RPS6KA3phosphorylation
up-regulates
HMGN2
PSer25
phosphorylation
down-regulates
HMGN211438671SIGNOR-249102
RPS6KA3phosphorylation
up-regulates
FOXN2
PSer369
phosphorylation
down-regulates
FOXN229396548SIGNOR-273841
RPS6KA3phosphorylation
up-regulates
NFATC4
PSer281
phosphorylation
up-regulates
NFATC417213202SIGNOR-234465
RPS6KA3phosphorylation
up-regulates
H2AX
PSer140
phosphorylation
up-regulates
H2AX21224359SIGNOR-279349
RPS6KA3phosphorylation
up-regulates
H2AX
PSer17
phosphorylation
up-regulates
H2AX21224359SIGNOR-279350
RPS6KA3phosphorylation
up-regulates
H3C1
PSer11
phosphorylation
down-regulates
H3C114625384SIGNOR-119229
RPS6KA3phosphorylation
up-regulates
TH
PSer40
phosphorylation
up-regulates
TH12421349SIGNOR-95483
RPS6KA3phosphorylation
up-regulates
KRT18
PSer53
phosphorylation
down-regulates
KRT187523419SIGNOR-248895
RPS6KA3phosphorylation
up-regulates
NFATC4
PSer676
phosphorylation
up-regulates
NFATC415657420SIGNOR-133283
RPS6KA3phosphorylation
up-regulates
TINF2
PSer295
phosphorylation
down-regulates
TINF223977114SIGNOR-202532
RPS6KA3phosphorylation
up-regulates
YBX1
PSer102
phosphorylation
up-regulates
YBX119036157SIGNOR-182165
RPS6KA3phosphorylation
up-regulates
PFKFB2
PSer466
phosphorylation
up-regulates
PFKFB22846551SIGNOR-23753
RPS6KA3phosphorylation
up-regulates
H3-3A
PSer11
phosphorylation
down-regulates
H3-3A15994958SIGNOR-138471
RPS6KA3phosphorylation
up-regulates
HMGN1
PSer7
phosphorylation
down-regulates
HMGN112773393SIGNOR-249215
RPS6KA3phosphorylation
up-regulates
RANBP3
PSer57
phosphorylation
up-regulates
RANBP318280241SIGNOR-276148
RPS6KA3phosphorylation
up-regulates
H3C1
PSer11
phosphorylation
down-regulates
H3C110464286SIGNOR-70436
RPS6KA3phosphorylation
up-regulates
MAP3K5
PThr1109
phosphorylation
down-regulates
MAP3K523608533SIGNOR-276463
RPS6KA3phosphorylation
up-regulates
TRAF6
PSer46
phosphorylation
up-regulates
TRAF629563609SIGNOR-278302
RPS6KA3phosphorylation
up-regulates
FGFR1
PSer789
phosphorylation
down-regulates
FGFR124141780SIGNOR-276599
RPS6KA3phosphorylation
up-regulates
NFATC4
PSer344
phosphorylation
up-regulates
NFATC417213202SIGNOR-235652
RPS6KA3phosphorylation
up-regulates
HMGN1
PSer21
phosphorylation
down-regulates
HMGN111438671SIGNOR-249100
RPS6KA3phosphorylation
up-regulates
H3-3A
PSer11
phosphorylation
down-regulates
H3-3A14625384SIGNOR-119225
RPS6KA3phosphorylation
up-regulates
TINF2
PSer330
phosphorylation
down-regulates
TINF223977114SIGNOR-202536
RPS6KA3phosphorylation
up-regulates
HMGN2
PSer29
phosphorylation
down-regulates
HMGN211438671SIGNOR-249103
RPS6KA3phosphorylation
up-regulates
NFATC4
PSer285
phosphorylation
up-regulates
NFATC417213202SIGNOR-234469
RPS6KA3phosphorylation
up-regulates
TH
PSer40
phosphorylation
up-regulates
TH7901013SIGNOR-34682
RPS6KA3phosphorylation
up-regulates
EIF2AK2
PThr451
phosphorylation
up-regulates
EIF2AK217404396SIGNOR-154183
RPS6KA3phosphorylation
up-regulates
FOXN2
PSer365
phosphorylation
down-regulates
FOXN229396548SIGNOR-273840
RPS6KA3phosphorylation
up-regulates
H3-3A
PSer11
phosphorylation
down-regulates
H3-3A10464286SIGNOR-70432
RPS6KA3phosphorylation
up-regulates
TH
PSer71
phosphorylation
up-regulates
TH7901013SIGNOR-34686
RPS6KA3phosphorylation
up-regulates
HMGN1
PSer25
phosphorylation
down-regulates
HMGN111438671SIGNOR-249101
RPS6KA3phosphorylation
up-regulates
MAP3K5
PSer83
phosphorylation
down-regulates
MAP3K523608533SIGNOR-276464
RPS6KA3phosphorylation
up-regulates
NFKBIA
PSer32
phosphorylation
down-regulates
NFKBIA20385620SIGNOR-279108
RPS6KA3phosphorylation
up-regulates
WWC1
PThr929
phosphorylation
up-regulates
WWC124269383SIGNOR-203306
RPS6KA3phosphorylation
up-regulates
GSK3A
PSer21
phosphorylation
down-regulates
GSK3A11583116SIGNOR-110827
RPS6KA3phosphorylation
up-regulates
TH
PSer71
phosphorylation
up-regulates
TH12421349SIGNOR-95487
RPS6KA3phosphorylation
up-regulates
KCNK3
PSer393
phosphorylation
up-regulates
KCNK321357689SIGNOR-172470
RPS6KA3phosphorylation
up-regulates
WWC1
PSer947
phosphorylation
up-regulates
WWC124269383SIGNOR-203302
RPS6KA3phosphorylation
up-regulates
BAD
PSer75
phosphorylation
down-regulates
BAD19282669SIGNOR-184595
RPS6KA3phosphorylation
up-regulates
ATF4
PSer245
phosphorylation
up-regulates
ATF415109498SIGNOR-124436
Regulator Mechanism/Effect Target SIGNOR-ID
RPS6KA3phosphorylation

down-regulates activity
H3C1SIGNOR-138475
RPS6KA3phosphorylation

up-regulates activity
PFKFB2SIGNOR-49367
RPS6KA3phosphorylation

unknown
NR4A1SIGNOR-249295
RPS6KA3phosphorylation

up-regulates activity
ATF1SIGNOR-280117
RPS6KA3phosphorylation

up-regulates activity
ATMSIGNOR-280118
RPS6KA3phosphorylation

up-regulates activity
SLC9A1SIGNOR-280119
RPS6KA3phosphorylation

unknown
H2BC3SIGNOR-174026
RPS6KA3phosphorylation

up-regulates activity
CREB1SIGNOR-248951
RPS6KA3phosphorylation

up-regulates activity
TP53SIGNOR-279567
RPS6KA3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
CASP8SIGNOR-272997
RPS6KA3phosphorylation

up-regulates
ESR1SIGNOR-182958
RPS6KA3phosphorylation

down-regulates activity
MAP3K5SIGNOR-276462
RPS6KA3phosphorylation

down-regulates activity
VGLL1SIGNOR-273842
RPS6KA3phosphorylation

up-regulates
NFATC4SIGNOR-234473
RPS6KA3phosphorylation
img/direct_inhibition.png
down-regulates
CICSIGNOR-169887
RPS6KA3phosphorylation

down-regulates activity
HMGN2SIGNOR-249102
RPS6KA3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FOXN2SIGNOR-273841
RPS6KA3phosphorylation

down-regulates activity
Histone H3SIGNOR-265347
RPS6KA3phosphorylation

up-regulates
NFATC4SIGNOR-234465
RPS6KA3phosphorylation

up-regulates activity
H2AXSIGNOR-279349
RPS6KA3phosphorylation

up-regulates activity
H2AXSIGNOR-279350
RPS6KA3phosphorylation

down-regulates activity
H3C1SIGNOR-119229
RPS6KA3phosphorylation

up-regulates
THSIGNOR-95483
RPS6KA3phosphorylation

unknown
KRT18SIGNOR-248895
RPS6KA3phosphorylation

up-regulates
NFATC4SIGNOR-133283
RPS6KA3phosphorylation

unknown
TINF2SIGNOR-202532
RPS6KA3phosphorylation

up-regulates
YBX1SIGNOR-182165
RPS6KA3phosphorylation

up-regulates activity
PFKFB2SIGNOR-23753
RPS6KA3phosphorylation

down-regulates activity
H3-3ASIGNOR-138471
RPS6KA3phosphorylation

unknown
HMGN1SIGNOR-249215
RPS6KA3phosphorylation

up-regulates quantity
RANBP3SIGNOR-276148
RPS6KA3phosphorylation

down-regulates activity
H3C1SIGNOR-70436
RPS6KA3phosphorylation

down-regulates activity
MAP3K5SIGNOR-276463
RPS6KA3phosphorylation

up-regulates activity
TRAF6SIGNOR-278302
RPS6KA3phosphorylation

down-regulates quantity
FGFR1SIGNOR-276599
RPS6KA3phosphorylation

up-regulates
NFATC4SIGNOR-235652
RPS6KA3phosphorylation

down-regulates activity
HMGN1SIGNOR-249100
RPS6KA3phosphorylation

down-regulates activity
H3-3ASIGNOR-119225
RPS6KA3phosphorylation

unknown
TINF2SIGNOR-202536
RPS6KA3phosphorylation

down-regulates activity
HMGN2SIGNOR-249103
RPS6KA3phosphorylation

up-regulates
NFATC4SIGNOR-234469
RPS6KA3phosphorylation

up-regulates
THSIGNOR-34682
RPS6KA3phosphorylation

up-regulates
EIF2AK2SIGNOR-154183
RPS6KA3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FOXN2SIGNOR-273840
RPS6KA3phosphorylation

down-regulates activity
H3-3ASIGNOR-70432
RPS6KA3phosphorylation

up-regulates
THSIGNOR-34686
RPS6KA3phosphorylation

down-regulates activity
HMGN1SIGNOR-249101
RPS6KA3phosphorylation

down-regulates activity
MAP3K5SIGNOR-276464
RPS6KA3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
NFKBIASIGNOR-279108
RPS6KA3phosphorylation

up-regulates
WWC1SIGNOR-203306
RPS6KA3phosphorylation

down-regulates activity
GSK3ASIGNOR-110827
RPS6KA3phosphorylation

up-regulates
THSIGNOR-95487
RPS6KA3phosphorylation

up-regulates activity
KCNK3SIGNOR-172470
RPS6KA3phosphorylation

up-regulates
WWC1SIGNOR-203302
RPS6KA3phosphorylation
img/direct_inhibition.png
down-regulates
BADSIGNOR-184595
RPS6KA3phosphorylation

up-regulates
ATF4SIGNOR-124436