| Name | RPS6KA3 |
| ID | P51812 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 1 68-327 PROSITE-ProRule
AGC-kinase C-terminal 328-397 PROSITE-ProRule
Protein kinase 2 422-679 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248320 |
| FYN | RPS6KA3 | Tyr529 | TITKTVEyLHAQGVV | phosphorylation up-regulates | 18156174 | SIGNOR-160048 |
| PPM1D | RPS6KA3 | Ser369 | TAKTPKDsPGIPPSA | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248321 |
| MAPK3 | RPS6KA3 | – | phosphorylation up-regulates | 19282669 | SIGNOR-184583 | |
| ERK1/2 | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | phosphorylation up-regulates | 10980595 | SIGNOR-244696 |
| MAPK7 | RPS6KA3 | – | phosphorylation up-regulates activity | 16626623 | SIGNOR-279216 | |
| AKT1 | RPS6KA3 | Ser19 | KMAVESPsDSAENGQ | phosphorylation down-regulates activity | 33574926 | SIGNOR-277548 |
| PPM1D | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248323 |
| ERK1/2 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 10980595 | SIGNOR-244692 |
| PPM1D | RPS6KA3 | Ser386 | HQLFRGFsFVAITSD | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248322 |
| SRC | RPS6KA3 | Tyr529 | TITKTVEyLHAQGVV | phosphorylation up-regulates | 18156174 | SIGNOR-160052 |
| MAPK3 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 10980595 | SIGNOR-81460 |
| ERK1/2 | RPS6KA3 | – | phosphorylation up-regulates | 19282669 | SIGNOR-244699 | |
| Gbeta | RPS6KA3 | – | phosphorylation up-regulates | 10980595 | SIGNOR-270014 | |
| MAPK3 | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | phosphorylation up-regulates | 10980595 | SIGNOR-81464 |
| PDPK1 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 19956600 | SIGNOR-161924 |
| MAPK1 | RPS6KA3 | – | phosphorylation up-regulates | 19282669 | SIGNOR-161518 | |
| PDPK1 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 10480933 | SIGNOR-70612 |
| FLT4 | RPS6KA3 | Tyr707 | KGAMAATySALNRNQ | phosphorylation down-regulates | 12601080 | SIGNOR-98708 |
| SRC | RPS6KA3 | Tyr488 | DVYDDGKyVYVVTEL | phosphorylation unknown | 18156174 | SIGNOR-160056 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PSer227 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248320 |
| FYN | phosphorylation up-regulates → | RPS6KA3 PTyr529 | phosphorylation up-regulates → | RPS6KA3 | 18156174 | SIGNOR-160048 |
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PSer369 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248321 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA3 PThr577 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-244696 |
| AKT1 | phosphorylation up-regulates → | RPS6KA3 PSer19 | phosphorylation down-regulates ⊣ | RPS6KA3 | 33574926 | SIGNOR-277548 |
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PThr577 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248323 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-244692 |
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PSer386 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248322 |
| SRC | phosphorylation up-regulates → | RPS6KA3 PTyr529 | phosphorylation up-regulates → | RPS6KA3 | 18156174 | SIGNOR-160052 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-81460 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA3 PThr577 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-81464 |
| PDPK1 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 19956600 | SIGNOR-161924 |
| PDPK1 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 10480933 | SIGNOR-70612 |
| FLT4 | phosphorylation up-regulates → | RPS6KA3 PTyr707 | phosphorylation down-regulates ⊣ | RPS6KA3 | 12601080 | SIGNOR-98708 |
| SRC | phosphorylation up-regulates → | RPS6KA3 PTyr488 | phosphorylation down-regulates ⊣ | RPS6KA3 | 18156174 | SIGNOR-160056 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248320 |
| FYN | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-160048 |
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248321 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-184583 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244696 |
| MAPK7 | phosphorylation → up-regulates activity | RPS6KA3 | SIGNOR-279216 |
| AKT1 | phosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-277548 |
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248323 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244692 |
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248322 |
| SRC | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-160052 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-81460 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244699 |
| Gbeta | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-270014 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-81464 |
| PDPK1 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-161924 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-161518 |
| PDPK1 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-70612 |
| FLT4 | phosphorylation down-regulates | RPS6KA3 | SIGNOR-98708 |
| SRC | phosphorylation → unknown | RPS6KA3 | SIGNOR-160056 |