| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248323 |
| MAPK3 | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | phosphorylation up-regulates | 10980595 | SIGNOR-81464 |
| ERK1/2 | RPS6KA3 | Thr577 | AENGLLMtPCYTANF | phosphorylation up-regulates | 10980595 | SIGNOR-244696 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PThr577 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248323 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA3 PThr577 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-81464 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA3 PThr577 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-244696 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248323 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-81464 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244696 |
