| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | dephosphorylation down-regulates activity | 15206906 | SIGNOR-248320 |
| ERK1/2 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 10980595 | SIGNOR-244692 |
| MAPK3 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 10980595 | SIGNOR-81460 |
| PDPK1 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 19956600 | SIGNOR-161924 |
| PDPK1 | RPS6KA3 | Ser227 | DHEKKAYsFCGTVEY | phosphorylation up-regulates | 10480933 | SIGNOR-70612 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | RPS6KA3 PSer227 | dephosphorylation up-regulates → | RPS6KA3 | 15206906 | SIGNOR-248320 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-244692 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 10980595 | SIGNOR-81460 |
| PDPK1 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 19956600 | SIGNOR-161924 |
| PDPK1 | phosphorylation up-regulates → | RPS6KA3 PSer227 | phosphorylation up-regulates → | RPS6KA3 | 10480933 | SIGNOR-70612 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → down-regulates activity | RPS6KA3 | SIGNOR-248320 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-244692 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-81460 |
| PDPK1 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-161924 |
| PDPK1 | phosphorylation → up-regulates | RPS6KA3 | SIGNOR-70612 |
