Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ERK1/2	RPS6KA3	Thr577 View in OncoXplorer	AENGLLMtPCYTANF	phosphorylation up-regulates	10980595	SIGNOR-244696
PPM1D	RPS6KA3	Thr577 View in OncoXplorer	AENGLLMtPCYTANF	dephosphorylation down-regulates activity	15206906	SIGNOR-248323
MAPK3	RPS6KA3	Thr577 View in OncoXplorer	AENGLLMtPCYTANF	phosphorylation up-regulates	10980595	SIGNOR-81464

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ERK1/2	phosphorylation up-regulates →	RPS6KA3 PThr577	phosphorylation up-regulates →	RPS6KA3	10980595	SIGNOR-244696
PPM1D	dephosphorylation down-regulates ⊣	RPS6KA3 PThr577	dephosphorylation up-regulates →	RPS6KA3	15206906	SIGNOR-248323
MAPK3	phosphorylation up-regulates →	RPS6KA3 PThr577	phosphorylation up-regulates →	RPS6KA3	10980595	SIGNOR-81464

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ERK1/2	phosphorylation → up-regulates	RPS6KA3	SIGNOR-244696
PPM1D	dephosphorylation → down-regulates activity	RPS6KA3	SIGNOR-248323
MAPK3	phosphorylation → up-regulates	RPS6KA3	SIGNOR-81464