| Name | BMX |
| ID | P51813 |
| Role | substrate |
| Enzymatic Domains |
PH 4-111 PROSITE-ProRule
SH2 296-392 PROSITE-ProRule
Protein kinase 417-675 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | BMX | Tyr40 | LTKTNLSyYEYDKMK | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254693 |
| TEC | BMX | Tyr216 | SSTSLAQyDSNSKKI | phosphorylation up-regulates activity | 12573241 | SIGNOR-246647 |
| BTK | BMX | Tyr224 | DSNSKKIyGSQPNFN | phosphorylation up-regulates | 12573241 | SIGNOR-98032 |
| ITK | BMX | Tyr224 | DSNSKKIyGSQPNFN | phosphorylation up-regulates activity | 12573241 | SIGNOR-251332 |
| TEC | BMX | Tyr224 | DSNSKKIyGSQPNFN | phosphorylation up-regulates | 12573241 | SIGNOR-98094 |
| BTK | BMX | Tyr216 | SSTSLAQyDSNSKKI | phosphorylation up-regulates | 12573241 | SIGNOR-98028 |
| ITK | BMX | Tyr216 | SSTSLAQyDSNSKKI | phosphorylation up-regulates activity | 12573241 | SIGNOR-251331 |
| SRC | BMX | Tyr566 | RYVLDDQyVSSVGTK | phosphorylation up-regulates | 10688651 | SIGNOR-75330 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | BMX PTyr40 | dephosphorylation up-regulates → | BMX | 25624455 | SIGNOR-254693 |
| TEC | phosphorylation up-regulates → | BMX PTyr216 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-246647 |
| BTK | phosphorylation up-regulates → | BMX PTyr224 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-98032 |
| ITK | phosphorylation up-regulates → | BMX PTyr224 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-251332 |
| TEC | phosphorylation up-regulates → | BMX PTyr224 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-98094 |
| BTK | phosphorylation up-regulates → | BMX PTyr216 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-98028 |
| ITK | phosphorylation up-regulates → | BMX PTyr216 | phosphorylation up-regulates → | BMX | 12573241 | SIGNOR-251331 |
| SRC | phosphorylation up-regulates → | BMX PTyr566 | phosphorylation up-regulates → | BMX | 10688651 | SIGNOR-75330 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → down-regulates activity | BMX | SIGNOR-254693 |
| TEC | phosphorylation → up-regulates activity | BMX | SIGNOR-246647 |
| BTK | phosphorylation → up-regulates | BMX | SIGNOR-98032 |
| ITK | phosphorylation → up-regulates activity | BMX | SIGNOR-251332 |
| TEC | phosphorylation → up-regulates | BMX | SIGNOR-98094 |
| BTK | phosphorylation → up-regulates | BMX | SIGNOR-98028 |
| ITK | phosphorylation → up-regulates activity | BMX | SIGNOR-251331 |
| SRC | phosphorylation → up-regulates | BMX | SIGNOR-75330 |