| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | CCNH | Ser304 | YEDDDYVsKKSKHEE | phosphorylation down-regulates | 10993082 | SIGNOR-82033 |
| CKM complex | CCNH | Ser304 | YEDDDYVsKKSKHEE | phosphorylation down-regulates activity | 10993082 | SIGNOR-273141 |
| CKM complex | CCNH | Ser5 | sSQKRHWT | phosphorylation down-regulates activity | 10993082 | SIGNOR-273139 |
| CDK8 | CCNH | Ser5 | sSQKRHWT | phosphorylation down-regulates | 10993082 | SIGNOR-82037 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK8 | phosphorylation up-regulates → | CCNH PSer304 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-82033 |
| CKM complex | phosphorylation up-regulates → | CCNH PSer304 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-273141 |
| CKM complex | phosphorylation up-regulates → | CCNH PSer5 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-273139 |
| CDK8 | phosphorylation up-regulates → | CCNH PSer5 | phosphorylation down-regulates ⊣ | CCNH | 10993082 | SIGNOR-82037 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK8 | phosphorylation down-regulates | CCNH | SIGNOR-82033 |
| CKM complex | phosphorylation → down-regulates activity | CCNH | SIGNOR-273141 |
| CKM complex | phosphorylation → down-regulates activity | CCNH | SIGNOR-273139 |
| CDK8 | phosphorylation down-regulates | CCNH | SIGNOR-82037 |
