| Name | JAK3 |
| ID | P52333 |
| Role | kinase |
| Enzymatic Domains |
FERM 24-356 PROSITE-ProRule
SH2; atypical 375-475
Protein kinase 1 521-781 PROSITE-ProRule
Protein kinase 2 822-1111 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK3 | PLD2 | Tyr415 | ALGINSGySKRALML | phosphorylation up-regulates | 20176813 | SIGNOR-163858 |
| JAK3 | NFATC1 | Tyr371 | ADFAPEDySSFQHIR | phosphorylation up-regulates activity | 23263556 | SIGNOR-276435 |
| JAK3 | JAK1 | – | phosphorylation up-regulates | 17259970 | SIGNOR-152917 | |
| JAK3 | JAK1 | Tyr1034 | AIETDKEyYTVKDDR | phosphorylation up-regulates activity | 12559972 | SIGNOR-251363 |
| JAK3 | JAK1 | Tyr1035 | IETDKEYyTVKDDRD | phosphorylation up-regulates activity | 12559972 | SIGNOR-251364 |
| JAK3 | CTNNB1 | Tyr30 | SHWQQQSyLDSGIHS | phosphorylation up-regulates activity | 28821617 | SIGNOR-278178 |
| JAK3 | CTNNB1 | Tyr64 | VDTSQVLyEWEQGFS | phosphorylation up-regulates activity | 28821617 | SIGNOR-278179 |
| JAK3 | CTNNB1 | Tyr86 | VADIDGQyAMTRAQR | phosphorylation up-regulates activity | 28821617 | SIGNOR-278180 |
| JAK3 | STAT3 | – | phosphorylation up-regulates | 30029643 | SIGNOR-256254 | |
| JAK3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 18250158 | SIGNOR-160672 |
| JAK3 | STAT5A | Tyr694 | LAKAVDGyVKPQIKQ | phosphorylation up-regulates | 19088846 | SIGNOR-182817 |
| JAK3 | JAK3 | Tyr981 | LPLDKDYyVVREPGQ | phosphorylation down-regulates | 9391116 | SIGNOR-53594 |
| JAK3 | JAK3 | Tyr785 | NSLISSDyELLSDPT | phosphorylation up-regulates | 18250158 | SIGNOR-160660 |
| JAK3 | JAK3 | Tyr904 | SLRLVMEyLPSGCLR | phosphorylation up-regulates | 18250158 | SIGNOR-160664 |
| JAK3 | JAK3 | Tyr939 | QICKGMEyLGSRRCV | phosphorylation up-regulates | 18250158 | SIGNOR-160668 |
| JAK3 | JAK3 | Tyr980 | LLPLDKDyYVVREPG | phosphorylation up-regulates | 9391116 | SIGNOR-53590 |
| JAK3 | EZH2 | Tyr244 | AEELKEKyKELTEQQ | phosphorylation up-regulates activity | 28868240 | SIGNOR-278518 |
| JAK3 | SIGLEC10 | Tyr691 | PKGTQADyAEVKFQ | phosphorylation unknown | 11733002 | SIGNOR-112487 |
| JAK3 | SIGLEC10 | Tyr597 | RHSTILDyINVVPTA | phosphorylation up-regulates | 11733002 | SIGNOR-112479 |
| JAK3 | SIGLEC10 | Tyr667 | ESQEELHyATLNFPG | phosphorylation up-regulates | 11733002 | SIGNOR-112483 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK3 | phosphorylation up-regulates → | PLD2 PTyr415 | phosphorylation up-regulates → | PLD2 | 20176813 | SIGNOR-163858 |
| JAK3 | phosphorylation up-regulates → | NFATC1 PTyr371 | phosphorylation up-regulates → | NFATC1 | 23263556 | SIGNOR-276435 |
| JAK3 | phosphorylation up-regulates → | JAK1 PTyr1034 | phosphorylation up-regulates → | JAK1 | 12559972 | SIGNOR-251363 |
| JAK3 | phosphorylation up-regulates → | JAK1 PTyr1035 | phosphorylation up-regulates → | JAK1 | 12559972 | SIGNOR-251364 |
| JAK3 | phosphorylation up-regulates → | CTNNB1 PTyr30 | phosphorylation up-regulates → | CTNNB1 | 28821617 | SIGNOR-278178 |
| JAK3 | phosphorylation up-regulates → | CTNNB1 PTyr64 | phosphorylation up-regulates → | CTNNB1 | 28821617 | SIGNOR-278179 |
| JAK3 | phosphorylation up-regulates → | CTNNB1 PTyr86 | phosphorylation up-regulates → | CTNNB1 | 28821617 | SIGNOR-278180 |
| JAK3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 18250158 | SIGNOR-160672 |
| JAK3 | phosphorylation up-regulates → | STAT5A PTyr694 | phosphorylation up-regulates → | STAT5A | 19088846 | SIGNOR-182817 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr981 | phosphorylation down-regulates ⊣ | JAK3 | 9391116 | SIGNOR-53594 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr785 | phosphorylation up-regulates → | JAK3 | 18250158 | SIGNOR-160660 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr904 | phosphorylation up-regulates → | JAK3 | 18250158 | SIGNOR-160664 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr939 | phosphorylation up-regulates → | JAK3 | 18250158 | SIGNOR-160668 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr980 | phosphorylation up-regulates → | JAK3 | 9391116 | SIGNOR-53590 |
| JAK3 | phosphorylation up-regulates → | EZH2 PTyr244 | phosphorylation up-regulates → | EZH2 | 28868240 | SIGNOR-278518 |
| JAK3 | phosphorylation up-regulates → | SIGLEC10 PTyr691 | phosphorylation down-regulates ⊣ | SIGLEC10 | 11733002 | SIGNOR-112487 |
| JAK3 | phosphorylation up-regulates → | SIGLEC10 PTyr597 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112479 |
| JAK3 | phosphorylation up-regulates → | SIGLEC10 PTyr667 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112483 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK3 | phosphorylation → up-regulates | PLD2 | SIGNOR-163858 |
| JAK3 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276435 |
| JAK3 | phosphorylation → up-regulates | JAK1 | SIGNOR-152917 |
| JAK3 | phosphorylation → up-regulates activity | JAK1 | SIGNOR-251363 |
| JAK3 | phosphorylation → up-regulates activity | JAK1 | SIGNOR-251364 |
| JAK3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278178 |
| JAK3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278179 |
| JAK3 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278180 |
| JAK3 | phosphorylation → up-regulates | STAT3 | SIGNOR-256254 |
| JAK3 | phosphorylation → up-regulates | STAT5A | SIGNOR-160672 |
| JAK3 | phosphorylation → up-regulates | STAT5A | SIGNOR-182817 |
| JAK3 | phosphorylation down-regulates | JAK3 | SIGNOR-53594 |
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-160660 |
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-160664 |
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-160668 |
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-53590 |
| JAK3 | phosphorylation → up-regulates activity | EZH2 | SIGNOR-278518 |
| JAK3 | phosphorylation → unknown | SIGLEC10 | SIGNOR-112487 |
| JAK3 | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112479 |
| JAK3 | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112483 |