| Name | JAK3 |
| ID | P52333 |
| Role | substrate |
| Enzymatic Domains |
FERM 24-356 PROSITE-ProRule
SH2; atypical 375-475
Protein kinase 1 521-781 PROSITE-ProRule
Protein kinase 2 822-1111 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK3 | JAK3 | Tyr980 | LLPLDKDyYVVREPG | phosphorylation up-regulates | 9391116 | SIGNOR-53590 |
| JAK3 | JAK3 | Tyr981 | LPLDKDYyVVREPGQ | phosphorylation down-regulates | 9391116 | SIGNOR-53594 |
| JAK1 | JAK3 | – | phosphorylation up-regulates | 17259970 | SIGNOR-152914 | |
| JAK3 | JAK3 | Tyr904 | SLRLVMEyLPSGCLR | phosphorylation up-regulates | 18250158 | SIGNOR-160664 |
| PTPN2 | JAK3 | – | dephosphorylation down-regulates activity | 15780598 | SIGNOR-133078 | |
| PTPN6 | JAK3 | – | dephosphorylation up-regulates | 11021818 | SIGNOR-82764 | |
| PTPRC | JAK3 | – | dephosphorylation up-regulates | 11994288 | SIGNOR-87157 | |
| JAK3 | JAK3 | Tyr785 | NSLISSDyELLSDPT | phosphorylation up-regulates | 18250158 | SIGNOR-160660 |
| PTPRC | JAK3 | – | dephosphorylation down-regulates activity | 11201744 | SIGNOR-248359 | |
| JAK3 | JAK3 | Tyr939 | QICKGMEyLGSRRCV | phosphorylation up-regulates | 18250158 | SIGNOR-160668 |
| IL15RA | JAK3 | – | phosphorylation up-regulates | 30029643 | SIGNOR-256225 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr980 | phosphorylation up-regulates → | JAK3 | 9391116 | SIGNOR-53590 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr981 | phosphorylation down-regulates ⊣ | JAK3 | 9391116 | SIGNOR-53594 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr904 | phosphorylation up-regulates → | JAK3 | 18250158 | SIGNOR-160664 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr785 | phosphorylation up-regulates → | JAK3 | 18250158 | SIGNOR-160660 |
| JAK3 | phosphorylation up-regulates → | JAK3 PTyr939 | phosphorylation up-regulates → | JAK3 | 18250158 | SIGNOR-160668 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-53590 |
| JAK3 | phosphorylation down-regulates | JAK3 | SIGNOR-53594 |
| JAK1 | phosphorylation → up-regulates | JAK3 | SIGNOR-152914 |
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-160664 |
| PTPN2 | dephosphorylation → down-regulates activity | JAK3 | SIGNOR-133078 |
| PTPN6 | dephosphorylation → up-regulates | JAK3 | SIGNOR-82764 |
| PTPRC | dephosphorylation → up-regulates | JAK3 | SIGNOR-87157 |
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-160660 |
| PTPRC | dephosphorylation → down-regulates activity | JAK3 | SIGNOR-248359 |
| JAK3 | phosphorylation → up-regulates | JAK3 | SIGNOR-160668 |
| IL15RA | phosphorylation → up-regulates | JAK3 | SIGNOR-256225 |