| Name | MAP2K6 |
| ID | P52564 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 53-314 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K6 | MAPK13 | – | phosphorylation up-regulates | 11242034 | SIGNOR-105698 | |
| MAP2K6 | MAPK13 | – | phosphorylation up-regulates | 8663074 | SIGNOR-42390 | |
| MAP2K6 | MAPK13 | Thr180 | RHADAEMtGYVVTRW | phosphorylation up-regulates activity | 10066767 | SIGNOR-273952 |
| MAP2K6 | MAPK13 | Tyr182 | ADAEMTGyVVTRWYR | phosphorylation up-regulates activity | 10066767 | SIGNOR-273951 |
| MAP2K6 | MAPK13 | Thr180 | RHADAEMtGYVVTRW | phosphorylation up-regulates activity | 9218798 | SIGNOR-251424 |
| MAP2K6 | MAPK9 | – | phosphorylation up-regulates | 8974401 | SIGNOR-45369 | |
| MAP2K6 | CRK | – | phosphorylation up-regulates | 8663074 | SIGNOR-42384 | |
| MAP2K6 | MAP2K6 | – | phosphorylation up-regulates activity | 10347227 | SIGNOR-236122 | |
| MAP2K6 | MAPK12 | Thr183 | RQADSEMtGYVVTRW | phosphorylation up-regulates | 19230643 | SIGNOR-184134 |
| MAP2K6 | MAPK12 | Tyr185 | ADSEMTGyVVTRWYR | phosphorylation up-regulates | 19230643 | SIGNOR-184138 |
| MAP2K6 | MAPK10 | – | phosphorylation up-regulates | 8974401 | SIGNOR-45363 | |
| MAP2K6 | STAT4 | Ser721 | PSDLLPMsPSVYAVL | phosphorylation up-regulates activity | 10961885 | SIGNOR-251425 |
| MAP2K6 | MAPK11 | – | phosphorylation up-regulates | 9430721 | SIGNOR-54947 | |
| MAP2K6 | MAPK14 | – | phosphorylation up-regulates activity | 10480932 | SIGNOR-70607 | |
| MAP2K6 | MAPK14 | – | phosphorylation up-regulates activity | 20551513 | SIGNOR-255780 | |
| MAP2K6 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-40423 |
| MAP2K6 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates activity | 8622669 | SIGNOR-40427 |
| MAP2K6 | MAPK14 | – | phosphorylation up-regulates activity | 8974401 | SIGNOR-236116 | |
| MAP2K6 | PAK6 | Tyr566 | KSLVGTPyWMAPEVI | phosphorylation up-regulates | 15550393 | SIGNOR-130975 |
| MAP2K6 | HSF4 | Thr471 | LGLPGALtIYSTPES | phosphorylation up-regulates activity | 24361130 | SIGNOR-275493 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K6 | phosphorylation up-regulates → | MAPK13 PThr180 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273952 |
| MAP2K6 | phosphorylation up-regulates → | MAPK13 PTyr182 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273951 |
| MAP2K6 | phosphorylation up-regulates → | MAPK13 PThr180 | phosphorylation up-regulates → | MAPK13 | 9218798 | SIGNOR-251424 |
| MAP2K6 | phosphorylation up-regulates → | MAPK12 PThr183 | phosphorylation up-regulates → | MAPK12 | 19230643 | SIGNOR-184134 |
| MAP2K6 | phosphorylation up-regulates → | MAPK12 PTyr185 | phosphorylation up-regulates → | MAPK12 | 19230643 | SIGNOR-184138 |
| MAP2K6 | phosphorylation up-regulates → | STAT4 PSer721 | phosphorylation up-regulates → | STAT4 | 10961885 | SIGNOR-251425 |
| MAP2K6 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40423 |
| MAP2K6 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40427 |
| MAP2K6 | phosphorylation up-regulates → | PAK6 PTyr566 | phosphorylation up-regulates → | PAK6 | 15550393 | SIGNOR-130975 |
| MAP2K6 | phosphorylation up-regulates → | HSF4 PThr471 | phosphorylation up-regulates → | HSF4 | 24361130 | SIGNOR-275493 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K6 | phosphorylation → up-regulates | MAPK13 | SIGNOR-105698 |
| MAP2K6 | phosphorylation → up-regulates | MAPK13 | SIGNOR-42390 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273952 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273951 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-251424 |
| MAP2K6 | phosphorylation → up-regulates | MAPK9 | SIGNOR-45369 |
| MAP2K6 | phosphorylation → up-regulates | CRK | SIGNOR-42384 |
| MAP2K6 | phosphorylation → up-regulates activity | MAP2K6 | SIGNOR-236122 |
| MAP2K6 | phosphorylation → up-regulates | MAPK12 | SIGNOR-184134 |
| MAP2K6 | phosphorylation → up-regulates | MAPK12 | SIGNOR-184138 |
| MAP2K6 | phosphorylation → up-regulates | MAPK10 | SIGNOR-45363 |
| MAP2K6 | phosphorylation → up-regulates activity | STAT4 | SIGNOR-251425 |
| MAP2K6 | phosphorylation → up-regulates | MAPK11 | SIGNOR-54947 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-70607 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-255780 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40423 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40427 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-236116 |
| MAP2K6 | phosphorylation → up-regulates | PAK6 | SIGNOR-130975 |
| MAP2K6 | phosphorylation → up-regulates activity | HSF4 | SIGNOR-275493 |