Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
EIF2AK2	MAP2K6	–		phosphorylation up-regulates activity	15229216	SIGNOR-279707
TAOK2	MAP2K6	Ser207 View in OncoXplorer	ISGYLVDsVAKTIDA	phosphorylation up-regulates activity	11279118	SIGNOR-106465
MAP3K7	MAP2K6	–		phosphorylation up-regulates activity	21902831	SIGNOR-236145
MAP3K7	MAP2K6	–		phosphorylation up-regulates activity	11460167	SIGNOR-109497
MAP3K1	MAP2K6	Thr211 View in OncoXplorer	LVDSVAKtIDAGCKP	phosphorylation up-regulates	9712898	SIGNOR-59679
MAP3K4	MAP2K6	–		phosphorylation up-regulates activity	9305639	SIGNOR-50894
MAP3K4	MAP2K6	–		phosphorylation up-regulates activity	9841871	SIGNOR-62372
MAP2K6	MAP2K6	–		phosphorylation up-regulates activity	10347227	SIGNOR-236122
MAP3K5	MAP2K6	–		phosphorylation up-regulates activity	8974401	SIGNOR-45353

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
TAOK2	phosphorylation up-regulates →	MAP2K6 PSer207	phosphorylation up-regulates →	MAP2K6	11279118	SIGNOR-106465
MAP3K1	phosphorylation up-regulates →	MAP2K6 PThr211	phosphorylation up-regulates →	MAP2K6	9712898	SIGNOR-59679

Regulator	Mechanism/Effect	Target	SIGNOR-ID
EIF2AK2	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-279707
TAOK2	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-106465
MAP3K7	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-236145
MAP3K7	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-109497
MAP3K1	phosphorylation → up-regulates	MAP2K6	SIGNOR-59679
MAP3K4	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-50894
MAP3K4	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-62372
MAP2K6	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-236122
MAP3K5	phosphorylation → up-regulates activity	MAP2K6	SIGNOR-45353