Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKCZ	ARHGDIA	–		phosphorylation up-regulates activity	17389234	SIGNOR-280089
FER	ARHGDIA	–		phosphorylation down-regulates activity	21122136	SIGNOR-279042
PLK1	ARHGDIA	Thr7 View in OncoXplorer	tAEQLAQI	phosphorylation up-regulates activity	38355643	SIGNOR-277883
PTPN12	ARHGDIA	–		dephosphorylation up-regulates activity	25666508	SIGNOR-277175
PAK1	ARHGDIA	Ser101 View in OncoXplorer	LESFKKQsFVLKEGV	phosphorylation down-regulates	15225553	SIGNOR-126650
PRKACA	ARHGDIA	Ser174	KGMLARGsYSIKSRF	phosphorylation down-regulates	18768928	SIGNOR-180576
PAK1	ARHGDIA	Ser174	KGMLARGsYSIKSRF	phosphorylation down-regulates	15225553	SIGNOR-126654
PLK1	ARHGDIA	Thr91	GPLELDLtGDLESFK	phosphorylation up-regulates activity	38355643	SIGNOR-277882
PRKCA	ARHGDIA	Ser34 View in OncoXplorer	YKPPAQKsIQEIQEL	phosphorylation down-regulates activity	25924946	SIGNOR-279097
SRC	ARHGDIA	Tyr156	YGPRAEEyEFLTPVE	phosphorylation down-regulates	16943322	SIGNOR-149282

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PLK1	phosphorylation up-regulates →	ARHGDIA PThr7	phosphorylation up-regulates →	ARHGDIA	38355643	SIGNOR-277883
PAK1	phosphorylation up-regulates →	ARHGDIA PSer101	phosphorylation down-regulates ⊣	ARHGDIA	15225553	SIGNOR-126650
PRKACA	phosphorylation up-regulates →	ARHGDIA PSer174	phosphorylation down-regulates ⊣	ARHGDIA	18768928	SIGNOR-180576
PAK1	phosphorylation up-regulates →	ARHGDIA PSer174	phosphorylation down-regulates ⊣	ARHGDIA	15225553	SIGNOR-126654
PLK1	phosphorylation up-regulates →	ARHGDIA PThr91	phosphorylation up-regulates →	ARHGDIA	38355643	SIGNOR-277882
PRKCA	phosphorylation up-regulates →	ARHGDIA PSer34	phosphorylation down-regulates ⊣	ARHGDIA	25924946	SIGNOR-279097
SRC	phosphorylation up-regulates →	ARHGDIA PTyr156	phosphorylation down-regulates ⊣	ARHGDIA	16943322	SIGNOR-149282

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKCZ	phosphorylation → up-regulates activity	ARHGDIA	SIGNOR-280089
FER	phosphorylation → down-regulates activity	ARHGDIA	SIGNOR-279042
PLK1	phosphorylation → up-regulates activity	ARHGDIA	SIGNOR-277883
PTPN12	dephosphorylation → up-regulates activity	ARHGDIA	SIGNOR-277175
PAK1	phosphorylation down-regulates	ARHGDIA	SIGNOR-126650
PRKACA	phosphorylation down-regulates	ARHGDIA	SIGNOR-180576
PAK1	phosphorylation down-regulates	ARHGDIA	SIGNOR-126654
PLK1	phosphorylation → up-regulates activity	ARHGDIA	SIGNOR-277882
PRKCA	phosphorylation → down-regulates activity	ARHGDIA	SIGNOR-279097
SRC	phosphorylation down-regulates	ARHGDIA	SIGNOR-149282