| Name | STAT2 |
| ID | P52630 |
| Role | substrate |
| Enzymatic Domains |
SH2 572-667 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | STAT2 | Ser393 | LTPEKGQsQGLIWDF | phosphorylation down-regulates quantity by destabilization | 31843895 | SIGNOR-276762 |
| GSK3A | STAT2 | Thr385 | ILTSNQKtLTPEKGQ | phosphorylation down-regulates quantity by destabilization | 31843895 | SIGNOR-276761 |
| GSK3B | STAT2 | Ser393 | LTPEKGQsQGLIWDF | phosphorylation down-regulates quantity by destabilization | 31843895 | SIGNOR-276764 |
| GSK3B | STAT2 | Ser381 | RKFNILTsNQKTLTP | phosphorylation down-regulates quantity by destabilization | 31843895 | SIGNOR-276763 |
| TYK2 | STAT2 | – | phosphorylation up-regulates activity | 27782195 | SIGNOR-279133 | |
| PTPRG | STAT2 | Tyr690 | NLQERRKyLKHRLIV | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254728 |
| JAK1 | STAT2 | Tyr690 | NLQERRKyLKHRLIV | phosphorylation up-regulates activity | 9020188 | SIGNOR-251344 |
| GSK3A | STAT2 | Ser381 | RKFNILTsNQKTLTP | phosphorylation down-regulates quantity by destabilization | 31843895 | SIGNOR-276760 |
| JAK1 | STAT2 | – | phosphorylation up-regulates activity | 9020188 | SIGNOR-88285 | |
| GSK3B | STAT2 | Thr385 | ILTSNQKtLTPEKGQ | phosphorylation down-regulates quantity by destabilization | 31843895 | SIGNOR-276765 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | phosphorylation up-regulates → | STAT2 PSer393 | phosphorylation down-regulates ⊣ | STAT2 | 31843895 | SIGNOR-276762 |
| GSK3A | phosphorylation up-regulates → | STAT2 PThr385 | phosphorylation down-regulates ⊣ | STAT2 | 31843895 | SIGNOR-276761 |
| GSK3B | phosphorylation up-regulates → | STAT2 PSer393 | phosphorylation down-regulates ⊣ | STAT2 | 31843895 | SIGNOR-276764 |
| GSK3B | phosphorylation up-regulates → | STAT2 PSer381 | phosphorylation down-regulates ⊣ | STAT2 | 31843895 | SIGNOR-276763 |
| PTPRG | dephosphorylation down-regulates ⊣ | STAT2 PTyr690 | dephosphorylation down-regulates ⊣ | STAT2 | 25624455 | SIGNOR-254728 |
| JAK1 | phosphorylation up-regulates → | STAT2 PTyr690 | phosphorylation up-regulates → | STAT2 | 9020188 | SIGNOR-251344 |
| GSK3A | phosphorylation up-regulates → | STAT2 PSer381 | phosphorylation down-regulates ⊣ | STAT2 | 31843895 | SIGNOR-276760 |
| GSK3B | phosphorylation up-regulates → | STAT2 PThr385 | phosphorylation down-regulates ⊣ | STAT2 | 31843895 | SIGNOR-276765 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3A | phosphorylation down-regulates quantity by destabilization | STAT2 | SIGNOR-276762 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | STAT2 | SIGNOR-276761 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | STAT2 | SIGNOR-276764 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | STAT2 | SIGNOR-276763 |
| TYK2 | phosphorylation → up-regulates activity | STAT2 | SIGNOR-279133 |
| PTPRG | dephosphorylation → up-regulates activity | STAT2 | SIGNOR-254728 |
| JAK1 | phosphorylation → up-regulates activity | STAT2 | SIGNOR-251344 |
| GSK3A | phosphorylation down-regulates quantity by destabilization | STAT2 | SIGNOR-276760 |
| JAK1 | phosphorylation → up-regulates activity | STAT2 | SIGNOR-88285 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | STAT2 | SIGNOR-276765 |