| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | STAT2 | Tyr690 | NLQERRKyLKHRLIV | dephosphorylation up-regulates activity | 25624455 | SIGNOR-254728 |
| JAK1 | STAT2 | Tyr690 | NLQERRKyLKHRLIV | phosphorylation up-regulates activity | 9020188 | SIGNOR-251344 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRG | dephosphorylation down-regulates ⊣ | STAT2 PTyr690 | dephosphorylation down-regulates ⊣ | STAT2 | 25624455 | SIGNOR-254728 |
| JAK1 | phosphorylation up-regulates → | STAT2 PTyr690 | phosphorylation up-regulates → | STAT2 | 9020188 | SIGNOR-251344 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRG | dephosphorylation → up-regulates activity | STAT2 | SIGNOR-254728 |
| JAK1 | phosphorylation → up-regulates activity | STAT2 | SIGNOR-251344 |
