| Name | VAV2 |
| ID | P52735 |
| Role | substrate |
| Enzymatic Domains |
Calponin-homology (CH) 1-120 PROSITE-ProRule
DH 198-376 PROSITE-ProRule
PH 405-512 PROSITE-ProRule
SH3 1 586-652 PROSITE-ProRule
SH2 673-767 PROSITE-ProRule
SH3 2 816-877 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | VAV2 | Tyr159 | HDLGEDIyDCVPCED | phosphorylation up-regulates | 12454019 | SIGNOR-95976 |
| NTRK2 | VAV2 | – | phosphorylation up-regulates activity | 21880903 | SIGNOR-280050 | |
| SRC | VAV2 | – | phosphorylation up-regulates activity | 11448999 | SIGNOR-280138 | |
| EGFR | VAV2 | Tyr142 | TENDDDVyRSLEELA | phosphorylation up-regulates | 12454019 | SIGNOR-95972 |
| EGFR | VAV2 | Tyr172 | EDGGDDIyEDIIKVE | phosphorylation up-regulates | 12454019 | SIGNOR-95980 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | VAV2 PTyr159 | phosphorylation up-regulates → | VAV2 | 12454019 | SIGNOR-95976 |
| EGFR | phosphorylation up-regulates → | VAV2 PTyr142 | phosphorylation up-regulates → | VAV2 | 12454019 | SIGNOR-95972 |
| EGFR | phosphorylation up-regulates → | VAV2 PTyr172 | phosphorylation up-regulates → | VAV2 | 12454019 | SIGNOR-95980 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation → up-regulates | VAV2 | SIGNOR-95976 |
| NTRK2 | phosphorylation → up-regulates activity | VAV2 | SIGNOR-280050 |
| SRC | phosphorylation → up-regulates activity | VAV2 | SIGNOR-280138 |
| EGFR | phosphorylation → up-regulates | VAV2 | SIGNOR-95972 |
| EGFR | phosphorylation → up-regulates | VAV2 | SIGNOR-95980 |