| Name | CHN2 |
| ID | P52757 |
| Role | substrate |
| Enzymatic Domains |
SH2 59-127 PROSITE-ProRule
Rho-GAP 277-468 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | CHN2 | Ser171 | EKVSRRLsRSKNEPR | phosphorylation down-regulates | 20335173 | SIGNOR-164687 |
| LCK | CHN2 | Tyr153 | KMTTNPIyEHIGYAT | phosphorylation down-regulates activity | 19201754 | SIGNOR-276240 |
| FYN | CHN2 | Tyr21 | VSSDAEEyQPPIWKS | phosphorylation down-regulates | 17560670 | SIGNOR-155709 |
| SRC | CHN2 | Tyr21 | VSSDAEEyQPPIWKS | phosphorylation down-regulates | 17560670 | SIGNOR-155713 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCD | phosphorylation up-regulates → | CHN2 PSer171 | phosphorylation down-regulates ⊣ | CHN2 | 20335173 | SIGNOR-164687 |
| LCK | phosphorylation up-regulates → | CHN2 PTyr153 | phosphorylation down-regulates ⊣ | CHN2 | 19201754 | SIGNOR-276240 |
| FYN | phosphorylation up-regulates → | CHN2 PTyr21 | phosphorylation down-regulates ⊣ | CHN2 | 17560670 | SIGNOR-155709 |
| SRC | phosphorylation up-regulates → | CHN2 PTyr21 | phosphorylation down-regulates ⊣ | CHN2 | 17560670 | SIGNOR-155713 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCD | phosphorylation down-regulates | CHN2 | SIGNOR-164687 |
| LCK | phosphorylation → down-regulates activity | CHN2 | SIGNOR-276240 |
| FYN | phosphorylation down-regulates | CHN2 | SIGNOR-155709 |
| SRC | phosphorylation down-regulates | CHN2 | SIGNOR-155713 |