| Name | HK2 |
| ID | P52789 |
| Role | substrate |
| Enzymatic Domains |
Hexokinase 1 16-458 PROSITE-ProRule
Hexokinase 2 464-906 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | HK2 | – | phosphorylation up-regulates activity | 31435020 | SIGNOR-259985 | |
| SRC | HK2 | – | phosphorylation up-regulates activity | 28054552 | SIGNOR-278499 | |
| AKT | HK2 | Thr473 | QHRARQKtLEHLQLS | phosphorylation up-regulates activity | 25323588 | SIGNOR-267576 |
| AKT1 | HK2 | Thr473 | QHRARQKtLEHLQLS | phosphorylation up-regulates activity | 31435020 | SIGNOR-259984 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | HK2 PThr473 | phosphorylation up-regulates → | HK2 | 25323588 | SIGNOR-267576 |
| AKT1 | phosphorylation up-regulates → | HK2 PThr473 | phosphorylation up-regulates → | HK2 | 31435020 | SIGNOR-259984 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates activity | HK2 | SIGNOR-259985 |
| SRC | phosphorylation → up-regulates activity | HK2 | SIGNOR-278499 |
| AKT | phosphorylation → up-regulates activity | HK2 | SIGNOR-267576 |
| AKT1 | phosphorylation → up-regulates activity | HK2 | SIGNOR-259984 |