| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | PDX1 | Thr11 | EEQYYAAtQLYKDPC | phosphorylation down-regulates activity | 24633305 | SIGNOR-278303 |
| GSK3B | PDX1 | Ser61 | LGALEQGsPPDISPY | phosphorylation down-regulates quantity | 16407209 | SIGNOR-255543 |
| PRKDC | PDX1 | Thr11 | EEQYYAAtQLYKDPC | phosphorylation down-regulates quantity by destabilization | 16166097 | SIGNOR-225542 |
| GSK3B | PDX1 | Ser272 | LSASPQPsSVAPRRP | phosphorylation down-regulates quantity | 19833727 | SIGNOR-255567 |
| GSK3B | PDX1 | Ser268 | LPPGLSAsPQPSSVA | phosphorylation down-regulates quantity | 19833727 | SIGNOR-255566 |
| HIPK2 | PDX1 | Ser268 | LPPGLSAsPQPSSVA | phosphorylation unknown | 20637728 | SIGNOR-255539 |
| GSK3B | PDX1 | Ser66 | QGSPPDIsPYEVPPL | phosphorylation down-regulates quantity | 16407209 | SIGNOR-255544 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK4 | phosphorylation up-regulates → | PDX1 PThr11 | phosphorylation down-regulates ⊣ | PDX1 | 24633305 | SIGNOR-278303 |
| GSK3B | phosphorylation up-regulates → | PDX1 PSer61 | phosphorylation down-regulates ⊣ | PDX1 | 16407209 | SIGNOR-255543 |
| PRKDC | phosphorylation up-regulates → | PDX1 PThr11 | phosphorylation down-regulates ⊣ | PDX1 | 16166097 | SIGNOR-225542 |
| GSK3B | phosphorylation up-regulates → | PDX1 PSer272 | phosphorylation down-regulates ⊣ | PDX1 | 19833727 | SIGNOR-255567 |
| GSK3B | phosphorylation up-regulates → | PDX1 PSer268 | phosphorylation down-regulates ⊣ | PDX1 | 19833727 | SIGNOR-255566 |
| HIPK2 | phosphorylation up-regulates → | PDX1 PSer268 | phosphorylation down-regulates ⊣ | PDX1 | 20637728 | SIGNOR-255539 |
| GSK3B | phosphorylation up-regulates → | PDX1 PSer66 | phosphorylation down-regulates ⊣ | PDX1 | 16407209 | SIGNOR-255544 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK4 | phosphorylation → down-regulates activity | PDX1 | SIGNOR-278303 |
| GSK3B | phosphorylation → down-regulates quantity | PDX1 | SIGNOR-255543 |
| PRKDC | phosphorylation down-regulates quantity by destabilization | PDX1 | SIGNOR-225542 |
| GSK3B | phosphorylation → down-regulates quantity | PDX1 | SIGNOR-255567 |
| GSK3B | phosphorylation → down-regulates quantity | PDX1 | SIGNOR-255566 |
| HIPK2 | phosphorylation → unknown | PDX1 | SIGNOR-255539 |
| GSK3B | phosphorylation → down-regulates quantity | PDX1 | SIGNOR-255544 |
