| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | PDX1 | Thr11 | EEQYYAAtQLYKDPC | phosphorylation down-regulates quantity by destabilization | 16166097 | SIGNOR-225542 |
| STK4 | PDX1 | Thr11 | EEQYYAAtQLYKDPC | phosphorylation down-regulates activity | 24633305 | SIGNOR-278303 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | phosphorylation up-regulates → | PDX1 PThr11 | phosphorylation down-regulates ⊣ | PDX1 | 16166097 | SIGNOR-225542 |
| STK4 | phosphorylation up-regulates → | PDX1 PThr11 | phosphorylation down-regulates ⊣ | PDX1 | 24633305 | SIGNOR-278303 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKDC | phosphorylation![]() down-regulates quantity by destabilization | PDX1 | SIGNOR-225542 |
| STK4 | phosphorylation → down-regulates activity | PDX1 | SIGNOR-278303 |