| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP5C | RAF1 | Ser338 | RPRGQRDsSYYWEIE | dephosphorylation down-regulates activity | 16892053 | SIGNOR-248537 |
| PPP5C | NR3C1 | Ser211 | PGKETNEsPWRSDLL | dephosphorylation down-regulates activity | 19586900 | SIGNOR-248538 |
| PPP5C | ABCB1 | Ser661 | SSNDSRSsLIRKRST | dephosphorylation down-regulates activity | 24333728 | SIGNOR-272505 |
| PPP5C | ABCB1 | Ser667 | SSLIRKRsTRRSVRG | dephosphorylation down-regulates activity | 24333728 | SIGNOR-272506 |
| PPP5C | ABCB1 | Ser671 | RKRSTRRsVRGSQAQ | dephosphorylation down-regulates activity | 24333728 | SIGNOR-272507 |
| PPP5C | CDC37 | Ser13 | VWDHIEVsDDEDETH | dephosphorylation down-regulates activity | 18922470 | SIGNOR-248539 |
| PPP5C | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | dephosphorylation down-regulates activity | 11689443 | SIGNOR-111301 |
| PPP5C | MAP3K5 | Thr842 | CTETFTGtLQYMAPE | dephosphorylation down-regulates activity | 11689443 | SIGNOR-248540 |
| PPP5C | CILK1 | Thr157 | IRSKPPYtDYVSTRW | dephosphorylation down-regulates activity | 16954377 | SIGNOR-248541 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP5C | dephosphorylation down-regulates ⊣ | RAF1 PSer338 | dephosphorylation up-regulates → | RAF1 | 16892053 | SIGNOR-248537 |
| PPP5C | dephosphorylation down-regulates ⊣ | NR3C1 PSer211 | dephosphorylation up-regulates → | NR3C1 | 19586900 | SIGNOR-248538 |
| PPP5C | dephosphorylation down-regulates ⊣ | ABCB1 PSer661 | dephosphorylation up-regulates → | ABCB1 | 24333728 | SIGNOR-272505 |
| PPP5C | dephosphorylation down-regulates ⊣ | ABCB1 PSer667 | dephosphorylation up-regulates → | ABCB1 | 24333728 | SIGNOR-272506 |
| PPP5C | dephosphorylation down-regulates ⊣ | ABCB1 PSer671 | dephosphorylation up-regulates → | ABCB1 | 24333728 | SIGNOR-272507 |
| PPP5C | dephosphorylation down-regulates ⊣ | CDC37 PSer13 | dephosphorylation up-regulates → | CDC37 | 18922470 | SIGNOR-248539 |
| PPP5C | dephosphorylation down-regulates ⊣ | MAP3K5 PThr838 | dephosphorylation up-regulates → | MAP3K5 | 11689443 | SIGNOR-111301 |
| PPP5C | dephosphorylation down-regulates ⊣ | MAP3K5 PThr842 | dephosphorylation up-regulates → | MAP3K5 | 11689443 | SIGNOR-248540 |
| PPP5C | dephosphorylation down-regulates ⊣ | CILK1 PThr157 | dephosphorylation up-regulates → | CILK1 | 16954377 | SIGNOR-248541 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP5C | dephosphorylation → down-regulates activity | RAF1 | SIGNOR-248537 |
| PPP5C | dephosphorylation → down-regulates activity | NR3C1 | SIGNOR-248538 |
| PPP5C | dephosphorylation → down-regulates activity | ABCB1 | SIGNOR-272505 |
| PPP5C | dephosphorylation → down-regulates activity | ABCB1 | SIGNOR-272506 |
| PPP5C | dephosphorylation → down-regulates activity | ABCB1 | SIGNOR-272507 |
| PPP5C | dephosphorylation → down-regulates activity | CDC37 | SIGNOR-248539 |
| PPP5C | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-111301 |
| PPP5C | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-248540 |
| PPP5C | dephosphorylation → down-regulates activity | CILK1 | SIGNOR-248541 |
