| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245255 |
| SRC | ACLY | Tyr227 | KVDATADyICKVKWG | phosphorylation up-regulates activity | 32420483 | SIGNOR-274108 |
| BCKDK | ACLY | – | phosphorylation up-regulates activity | 35070754 | SIGNOR-280194 | |
| GSK3B | ACLY | Ser451 | STSTPAPsRTASFSE | phosphorylation up-regulates activity | 10653665 | SIGNOR-251218 |
| AKT | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245259 |
| SRC | ACLY | Tyr252 | EAYPEEAyIADLDAK | phosphorylation up-regulates activity | 32420483 | SIGNOR-274109 |
| LYN | ACLY | Tyr682 | SRTTDGVyEGVAIGG | phosphorylation up-regulates activity | 32420483 | SIGNOR-274103 |
| LYN | ACLY | Tyr227 | KVDATADyICKVKWG | phosphorylation up-regulates activity | 32420483 | SIGNOR-274104 |
| LYN | ACLY | – | phosphorylation up-regulates activity | 32420483 | SIGNOR-279743 | |
| LYN | ACLY | Tyr252 | EAYPEEAyIADLDAK | phosphorylation up-regulates activity | 32420483 | SIGNOR-274105 |
| SRC | ACLY | Tyr682 | SRTTDGVyEGVAIGG | phosphorylation up-regulates activity | 32420483 | SIGNOR-274106 |
| AKT2 | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245263 |
| MTOR | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation up-regulates activity | 27015560 | SIGNOR-278962 |
| GSK3B | ACLY | Thr447 | NASGSTStPAPSRTA | phosphorylation up-regulates activity | 10653665 | SIGNOR-251219 |
| SRC | ACLY | Tyr1006 | PATPLLDyALEVEKI | phosphorylation up-regulates activity | 32420483 | SIGNOR-274107 |
| PRKACA | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation up-regulates activity | 10653665 | SIGNOR-250328 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245255 |
| SRC | phosphorylation up-regulates → | ACLY PTyr227 | phosphorylation up-regulates → | ACLY | 32420483 | SIGNOR-274108 |
| GSK3B | phosphorylation up-regulates → | ACLY PSer451 | phosphorylation up-regulates → | ACLY | 10653665 | SIGNOR-251218 |
| AKT | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245259 |
| SRC | phosphorylation up-regulates → | ACLY PTyr252 | phosphorylation up-regulates → | ACLY | 32420483 | SIGNOR-274109 |
| LYN | phosphorylation up-regulates → | ACLY PTyr682 | phosphorylation up-regulates → | ACLY | 32420483 | SIGNOR-274103 |
| LYN | phosphorylation up-regulates → | ACLY PTyr227 | phosphorylation up-regulates → | ACLY | 32420483 | SIGNOR-274104 |
| LYN | phosphorylation up-regulates → | ACLY PTyr252 | phosphorylation up-regulates → | ACLY | 32420483 | SIGNOR-274105 |
| SRC | phosphorylation up-regulates → | ACLY PTyr682 | phosphorylation up-regulates → | ACLY | 32420483 | SIGNOR-274106 |
| AKT2 | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245263 |
| MTOR | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation up-regulates → | ACLY | 27015560 | SIGNOR-278962 |
| GSK3B | phosphorylation up-regulates → | ACLY PThr447 | phosphorylation up-regulates → | ACLY | 10653665 | SIGNOR-251219 |
| SRC | phosphorylation up-regulates → | ACLY PTyr1006 | phosphorylation up-regulates → | ACLY | 32420483 | SIGNOR-274107 |
| PRKACA | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation up-regulates → | ACLY | 10653665 | SIGNOR-250328 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → unknown | ACLY | SIGNOR-245255 |
| SRC | phosphorylation → up-regulates activity | ACLY | SIGNOR-274108 |
| BCKDK | phosphorylation → up-regulates activity | ACLY | SIGNOR-280194 |
| GSK3B | phosphorylation → up-regulates activity | ACLY | SIGNOR-251218 |
| AKT | phosphorylation → unknown | ACLY | SIGNOR-245259 |
| SRC | phosphorylation → up-regulates activity | ACLY | SIGNOR-274109 |
| LYN | phosphorylation → up-regulates activity | ACLY | SIGNOR-274103 |
| LYN | phosphorylation → up-regulates activity | ACLY | SIGNOR-274104 |
| LYN | phosphorylation → up-regulates activity | ACLY | SIGNOR-279743 |
| LYN | phosphorylation → up-regulates activity | ACLY | SIGNOR-274105 |
| SRC | phosphorylation → up-regulates activity | ACLY | SIGNOR-274106 |
| AKT2 | phosphorylation → unknown | ACLY | SIGNOR-245263 |
| MTOR | phosphorylation → up-regulates activity | ACLY | SIGNOR-278962 |
| GSK3B | phosphorylation → up-regulates activity | ACLY | SIGNOR-251219 |
| SRC | phosphorylation → up-regulates activity | ACLY | SIGNOR-274107 |
| PRKACA | phosphorylation → up-regulates activity | ACLY | SIGNOR-250328 |
