Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT1	ACLY	Ser455 View in OncoXplorer	PAPSRTAsFSESRAD	phosphorylation unknown	12107176	SIGNOR-245255
AKT	ACLY	Ser455 View in OncoXplorer	PAPSRTAsFSESRAD	phosphorylation unknown	12107176	SIGNOR-245259
AKT2	ACLY	Ser455 View in OncoXplorer	PAPSRTAsFSESRAD	phosphorylation unknown	12107176	SIGNOR-245263
MTOR	ACLY	Ser455 View in OncoXplorer	PAPSRTAsFSESRAD	phosphorylation up-regulates activity	27015560	SIGNOR-278962
PRKACA	ACLY	Ser455 View in OncoXplorer	PAPSRTAsFSESRAD	phosphorylation up-regulates activity	10653665	SIGNOR-250328

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT1	phosphorylation up-regulates →	ACLY PSer455	phosphorylation down-regulates ⊣	ACLY	12107176	SIGNOR-245255
AKT	phosphorylation up-regulates →	ACLY PSer455	phosphorylation down-regulates ⊣	ACLY	12107176	SIGNOR-245259
AKT2	phosphorylation up-regulates →	ACLY PSer455	phosphorylation down-regulates ⊣	ACLY	12107176	SIGNOR-245263
MTOR	phosphorylation up-regulates →	ACLY PSer455	phosphorylation up-regulates →	ACLY	27015560	SIGNOR-278962
PRKACA	phosphorylation up-regulates →	ACLY PSer455	phosphorylation up-regulates →	ACLY	10653665	SIGNOR-250328

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT1	phosphorylation → unknown	ACLY	SIGNOR-245255
AKT	phosphorylation → unknown	ACLY	SIGNOR-245259
AKT2	phosphorylation → unknown	ACLY	SIGNOR-245263
MTOR	phosphorylation → up-regulates activity	ACLY	SIGNOR-278962
PRKACA	phosphorylation → up-regulates activity	ACLY	SIGNOR-250328