| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245255 |
| PRKACA | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation up-regulates activity | 10653665 | SIGNOR-250328 |
| AKT | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245259 |
| AKT2 | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation unknown | 12107176 | SIGNOR-245263 |
| MTOR | ACLY | Ser455 | PAPSRTAsFSESRAD | phosphorylation up-regulates activity | 27015560 | SIGNOR-278962 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT1 | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245255 |
| PRKACA | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation up-regulates → | ACLY | 10653665 | SIGNOR-250328 |
| AKT | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245259 |
| AKT2 | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation down-regulates ⊣ | ACLY | 12107176 | SIGNOR-245263 |
| MTOR | phosphorylation up-regulates → | ACLY PSer455 | phosphorylation up-regulates → | ACLY | 27015560 | SIGNOR-278962 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT1 | phosphorylation → unknown | ACLY | SIGNOR-245255 |
| PRKACA | phosphorylation → up-regulates activity | ACLY | SIGNOR-250328 |
| AKT | phosphorylation → unknown | ACLY | SIGNOR-245259 |
| AKT2 | phosphorylation → unknown | ACLY | SIGNOR-245263 |
| MTOR | phosphorylation → up-regulates activity | ACLY | SIGNOR-278962 |
