| Name | LIMK1 |
| ID | P53667 |
| Role | kinase |
| Enzymatic Domains |
LIM zinc-binding 1 25-75 PROSITE-ProRule
LIM zinc-binding 2 84-137 PROSITE-ProRule
PDZ 165-258 PROSITE-ProRule
Protein kinase 339-604 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LIMK1 | AURKA | – | phosphorylation up-regulates activity | 22214762 | SIGNOR-276400 | |
| LIMK1 | CFL1 | Ser3 | sGVAVSDG | phosphorylation down-regulates | 18079118 | SIGNOR-159885 |
| LIMK1 | CFL2 | Ser3 | sGVTVNDE | phosphorylation down-regulates activity | 9655398 | SIGNOR-58596 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LIMK1 | phosphorylation up-regulates → | CFL1 PSer3 | phosphorylation down-regulates ⊣ | CFL1 | 18079118 | SIGNOR-159885 |
| LIMK1 | phosphorylation up-regulates → | CFL2 PSer3 | phosphorylation down-regulates ⊣ | CFL2 | 9655398 | SIGNOR-58596 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LIMK1 | phosphorylation → up-regulates activity | AURKA | SIGNOR-276400 |
| LIMK1 | phosphorylation down-regulates | CFL1 | SIGNOR-159885 |
| LIMK1 | phosphorylation → down-regulates activity | CFL2 | SIGNOR-58596 |