| Name | LIMK1 |
| ID | P53667 |
| Role | substrate |
| Enzymatic Domains |
LIM zinc-binding 1 25-75 PROSITE-ProRule
LIM zinc-binding 2 84-137 PROSITE-ProRule
PDZ 165-258 PROSITE-ProRule
Protein kinase 339-604 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC42BPA | LIMK1 | Thr508 | PDRKKRYtVVGNPYW | phosphorylation up-regulates activity | 11340065 | SIGNOR-250721 |
| AURKA | LIMK1 | – | phosphorylation up-regulates activity | 25090971 | SIGNOR-279799 | |
| PAK1 | LIMK1 | Thr508 | PDRKKRYtVVGNPYW | phosphorylation up-regulates activity | 10559936 | SIGNOR-72142 |
| SSH1 | LIMK1 | – | dephosphorylation down-regulates activity | 23153585 | SIGNOR-277096 | |
| AURKA | LIMK1 | Ser307 | DRSPGAGsLGSPASQ | phosphorylation up-regulates activity | 22214762 | SIGNOR-276399 |
| ROCK1 | LIMK1 | Thr508 | PDRKKRYtVVGNPYW | phosphorylation up-regulates activity | 10652353 | SIGNOR-74569 |
| PAK6 | LIMK1 | Thr508 | PDRKKRYtVVGNPYW | phosphorylation up-regulates activity | 25714010 | SIGNOR-278970 |
| PTPRG | LIMK1 | Tyr507 | KPDRKKRyTVVGNPY | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254711 |
| CAMK4 | LIMK1 | Thr508 | PDRKKRYtVVGNPYW | phosphorylation up-regulates activity | 19696021 | SIGNOR-280201 |
| MAPKAPK2 | LIMK1 | Ser323 | KDLGRSEsLRVVCRP | phosphorylation up-regulates | 16456544 | SIGNOR-144333 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC42BPA | phosphorylation up-regulates → | LIMK1 PThr508 | phosphorylation up-regulates → | LIMK1 | 11340065 | SIGNOR-250721 |
| PAK1 | phosphorylation up-regulates → | LIMK1 PThr508 | phosphorylation up-regulates → | LIMK1 | 10559936 | SIGNOR-72142 |
| AURKA | phosphorylation up-regulates → | LIMK1 PSer307 | phosphorylation up-regulates → | LIMK1 | 22214762 | SIGNOR-276399 |
| ROCK1 | phosphorylation up-regulates → | LIMK1 PThr508 | phosphorylation up-regulates → | LIMK1 | 10652353 | SIGNOR-74569 |
| PAK6 | phosphorylation up-regulates → | LIMK1 PThr508 | phosphorylation up-regulates → | LIMK1 | 25714010 | SIGNOR-278970 |
| PTPRG | dephosphorylation down-regulates ⊣ | LIMK1 PTyr507 | dephosphorylation up-regulates → | LIMK1 | 25624455 | SIGNOR-254711 |
| CAMK4 | phosphorylation up-regulates → | LIMK1 PThr508 | phosphorylation up-regulates → | LIMK1 | 19696021 | SIGNOR-280201 |
| MAPKAPK2 | phosphorylation up-regulates → | LIMK1 PSer323 | phosphorylation up-regulates → | LIMK1 | 16456544 | SIGNOR-144333 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC42BPA | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-250721 |
| AURKA | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-279799 |
| PAK1 | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-72142 |
| SSH1 | dephosphorylation → down-regulates activity | LIMK1 | SIGNOR-277096 |
| AURKA | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-276399 |
| ROCK1 | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-74569 |
| PAK6 | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-278970 |
| PTPRG | dephosphorylation → down-regulates activity | LIMK1 | SIGNOR-254711 |
| CAMK4 | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-280201 |
| MAPKAPK2 | phosphorylation → up-regulates | LIMK1 | SIGNOR-144333 |