Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
LIMK2	SPOP	Ser171	VQDSVNIsGQNTMNM	phosphorylation down-regulates activity	33311589	SIGNOR-278339
LIMK2	SPOP	Ser226	AARSPVFsAMFEHEM	phosphorylation down-regulates activity	33311589	SIGNOR-278338
LIMK2	SPOP	Ser59	IKSSTFSsGANDKLK	phosphorylation down-regulates activity	33311589	SIGNOR-278337
LIMK2	CFL1	Ser3	sGVAVSDG	phosphorylation down-regulates activity	11171090	SIGNOR-105098
LIMK2	PTEN	–		phosphorylation down-regulates activity	32931887	SIGNOR-278363
LIMK2	TWIST1	–		phosphorylation up-regulates quantity	30716360	SIGNOR-278952
LIMK2	SRPK1	–		phosphorylation up-regulates activity	32859889	SIGNOR-279625
LIMK2	NKX3-1	Ser185	KTKRKQLsSELGDLE	phosphorylation down-regulates activity	34066036	SIGNOR-278951

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
LIMK2	phosphorylation up-regulates →	SPOP PSer171	phosphorylation down-regulates ⊣	SPOP	33311589	SIGNOR-278339
LIMK2	phosphorylation up-regulates →	SPOP PSer226	phosphorylation down-regulates ⊣	SPOP	33311589	SIGNOR-278338
LIMK2	phosphorylation up-regulates →	SPOP PSer59	phosphorylation down-regulates ⊣	SPOP	33311589	SIGNOR-278337
LIMK2	phosphorylation up-regulates →	CFL1 PSer3	phosphorylation down-regulates ⊣	CFL1	11171090	SIGNOR-105098
LIMK2	phosphorylation up-regulates →	NKX3-1 PSer185	phosphorylation down-regulates ⊣	NKX3-1	34066036	SIGNOR-278951

Regulator	Mechanism/Effect	Target	SIGNOR-ID
LIMK2	phosphorylation → down-regulates activity	SPOP	SIGNOR-278339
LIMK2	phosphorylation → down-regulates activity	SPOP	SIGNOR-278338
LIMK2	phosphorylation → down-regulates activity	SPOP	SIGNOR-278337
LIMK2	phosphorylation → down-regulates activity	CFL1	SIGNOR-105098
LIMK2	phosphorylation → down-regulates activity	PTEN	SIGNOR-278363
LIMK2	phosphorylation → up-regulates quantity	TWIST1	SIGNOR-278952
LIMK2	phosphorylation → up-regulates activity	SRPK1	SIGNOR-279625
LIMK2	phosphorylation → down-regulates activity	NKX3-1	SIGNOR-278951