Entity Details

Name LIMK2
ID P53671
Role substrate
Enzymatic Domains
LIM zinc-binding 1 12-63
PROSITE-ProRule
LIM zinc-binding 2 72-124
PROSITE-ProRule
PDZ 152-239
PROSITE-ProRule
Protein kinase 331-608
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCDLIMK2Ser283EGTLRRRsLRRSNSIphosphorylation
down-regulates		16820362SIGNOR-147716
ROCK1LIMK2Thr505NDRKKRYtVVGNPYWphosphorylation
up-regulates		11018042SIGNOR-82755
PRKCDLIMK2Ser283EGTLRRRsLRRSNSIphosphorylation
down-regulates		15923181SIGNOR-137927
ROCK1LIMK2Thr526NGKSYDEtVDIFSFGphosphorylation
up-regulates activity		11018042SIGNOR-249053
CDC42BPALIMK2Thr505NDRKKRYtVVGNPYWphosphorylation
up-regulates activity		11340065SIGNOR-107584
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCDphosphorylation
up-regulates
→
LIMK2
PSer283		phosphorylation
down-regulates
⊣		LIMK216820362SIGNOR-147716
ROCK1phosphorylation
up-regulates
→
LIMK2
PThr505		phosphorylation
up-regulates
→		LIMK211018042SIGNOR-82755
PRKCDphosphorylation
up-regulates
→
LIMK2
PSer283		phosphorylation
down-regulates
⊣		LIMK215923181SIGNOR-137927
ROCK1phosphorylation
up-regulates
→
LIMK2
PThr526		phosphorylation
up-regulates
→		LIMK211018042SIGNOR-249053
CDC42BPAphosphorylation
up-regulates
→
LIMK2
PThr505		phosphorylation
up-regulates
→		LIMK211340065SIGNOR-107584
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCDphosphorylation
img/direct_inhibition.png
down-regulates 		LIMK2SIGNOR-147716
ROCK1phosphorylation
→
up-regulates 		LIMK2SIGNOR-82755
PRKCDphosphorylation
img/direct_inhibition.png
down-regulates 		LIMK2SIGNOR-137927
ROCK1phosphorylation
→
up-regulates activity 		LIMK2SIGNOR-249053
CDC42BPAphosphorylation
→
up-regulates activity 		LIMK2SIGNOR-107584