| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | RCAN1 | Ser163 | PDKQFLIsPPASPPV | phosphorylation up-regulates activity | 12063245 | SIGNOR-249359 |
| MAP3K3 | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates | 16126726 | SIGNOR-138945 |
| MAP3K3 | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates | 12809556 | SIGNOR-102294 |
| DYRK1A | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates | 12809556 | SIGNOR-102290 |
| LRRK2 | RCAN1 | – | phosphorylation up-regulates activity | 28553204 | SIGNOR-278340 | |
| Gbeta | RCAN1 | – | phosphorylation up-regulates activity | 12063245 | SIGNOR-270026 | |
| ERK1/2 | RCAN1 | – | phosphorylation up-regulates activity | 12063245 | SIGNOR-270149 | |
| MAPK3 | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates activity | 12063245 | SIGNOR-249478 |
| MAP3K7 | RCAN1 | – | phosphorylation up-regulates activity | 19136967 | SIGNOR-279535 | |
| MAPK1 | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates activity | 12063245 | SIGNOR-249198 |
| DYRK1A | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates | 16126726 | SIGNOR-139958 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | RCAN1 PSer163 | phosphorylation up-regulates → | RCAN1 | 12063245 | SIGNOR-249359 |
| MAP3K3 | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 16126726 | SIGNOR-138945 |
| MAP3K3 | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 12809556 | SIGNOR-102294 |
| DYRK1A | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 12809556 | SIGNOR-102290 |
| MAPK3 | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 12063245 | SIGNOR-249478 |
| MAPK1 | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 12063245 | SIGNOR-249198 |
| DYRK1A | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 16126726 | SIGNOR-139958 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-249359 |
| MAP3K3 | phosphorylation → up-regulates | RCAN1 | SIGNOR-138945 |
| MAP3K3 | phosphorylation → up-regulates | RCAN1 | SIGNOR-102294 |
| DYRK1A | phosphorylation → up-regulates | RCAN1 | SIGNOR-102290 |
| LRRK2 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-278340 |
| Gbeta | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-270026 |
| ERK1/2 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-270149 |
| MAPK3 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-249478 |
| MAP3K7 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-279535 |
| MAPK1 | phosphorylation → up-regulates activity | RCAN1 | SIGNOR-249198 |
| DYRK1A | phosphorylation → up-regulates | RCAN1 | SIGNOR-139958 |
