| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | BLM | Thr182 | SHFVRVStAQKSKKG | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276909 |
| TTK | BLM | – | phosphorylation up-regulates activity | 23700430 | SIGNOR-280156 | |
| CyclinA2/CDK2 | BLM | Ser175 | SFVTPPQsHFVRVST | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276910 |
| CHEK1 | BLM | Ser646 | LKHERFQsLSFPHTK | phosphorylation up-regulates | 20719863 | SIGNOR-167534 |
| CyclinA2/CDK2 | BLM | Thr171 | ETSKSFVtPPQSHFV | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276907 |
| ATM | BLM | Thr99 | NAPAGQEtQRGGSKS | phosphorylation up-regulates | 12034743 | SIGNOR-88010 |
| GSK3B | BLM | Thr171 | ETSKSFVtPPQSHFV | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276906 |
| GSK3B | BLM | Ser175 | SFVTPPQsHFVRVST | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276911 |
| ATR | BLM | – | phosphorylation up-regulates activity | 11916980 | SIGNOR-278978 | |
| CHEK2 | BLM | Thr182 | SHFVRVStAQKSKKG | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276908 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | BLM PThr182 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276909 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | BLM PSer175 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276910 |
| CHEK1 | phosphorylation up-regulates → | BLM PSer646 | phosphorylation up-regulates → | BLM | 20719863 | SIGNOR-167534 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | BLM PThr171 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276907 |
| ATM | phosphorylation up-regulates → | BLM PThr99 | phosphorylation up-regulates → | BLM | 12034743 | SIGNOR-88010 |
| GSK3B | phosphorylation up-regulates → | BLM PThr171 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276906 |
| GSK3B | phosphorylation up-regulates → | BLM PSer175 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276911 |
| CHEK2 | phosphorylation up-regulates → | BLM PThr182 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276908 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276909 |
| TTK | phosphorylation → up-regulates activity | BLM | SIGNOR-280156 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276910 |
| CHEK1 | phosphorylation → up-regulates | BLM | SIGNOR-167534 |
| CyclinA2/CDK2 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276907 |
| ATM | phosphorylation → up-regulates | BLM | SIGNOR-88010 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276906 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276911 |
| ATR | phosphorylation → up-regulates activity | BLM | SIGNOR-278978 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276908 |
