Entity Details

Name ATXN3
ID P54252
Role substrate
Enzymatic Domains
Josephin 1-180
PROSITE-ProRule
UIM 1 224-243
PROSITE-ProRule
UIM 2 244-263
PROSITE-ProRule
UIM 3 331-349
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CSNK2A1ATXN3Ser335SDLGDAMsEEDMLQAphosphorylation
up-regulates activity		19542537SIGNOR-276226
CSNK2A1ATXN3Ser347LQAAVTMsLETVRNDphosphorylation
up-regulates activity		19542537SIGNOR-276224
CSNK2A1ATXN3Ser236LQRALALsRQEIDMEphosphorylation
up-regulates activity		19542537SIGNOR-276225
GSK3BATXN3Ser256LRRAIQLsMQGSSRNphosphorylation
up-regulates quantity by stabilization		17434145SIGNOR-264821
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CSNK2A1phosphorylation
up-regulates
→
ATXN3
PSer335		phosphorylation
up-regulates
→		ATXN319542537SIGNOR-276226
CSNK2A1phosphorylation
up-regulates
→
ATXN3
PSer347		phosphorylation
up-regulates
→		ATXN319542537SIGNOR-276224
CSNK2A1phosphorylation
up-regulates
→
ATXN3
PSer236		phosphorylation
up-regulates
→		ATXN319542537SIGNOR-276225
GSK3Bphosphorylation
up-regulates
→
ATXN3
PSer256		phosphorylation
up-regulates
→		ATXN317434145SIGNOR-264821
Regulator Mechanism/Effect Target SIGNOR-ID
CSNK2A1phosphorylation
→
up-regulates activity 		ATXN3SIGNOR-276226
CSNK2A1phosphorylation
→
up-regulates activity 		ATXN3SIGNOR-276224
CSNK2A1phosphorylation
→
up-regulates activity 		ATXN3SIGNOR-276225
GSK3Bphosphorylation
→
up-regulates quantity by stabilization 		ATXN3SIGNOR-264821