Entity Details

Name EPHA4
ID P54764
Role kinase
Enzymatic Domains
Eph LBD 30-209
PROSITE-ProRule
Fibronectin type-III 1 328-439
PROSITE-ProRule
Fibronectin type-III 2 440-537
PROSITE-ProRule
Protein kinase 621-882
PROSITE-ProRule
SAM 911-975
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
EPHA4JAK2–phosphorylation
up-regulates activity		28686668SIGNOR-279040
EPHA4GHR–phosphorylation
up-regulates activity		28686668SIGNOR-279461
EPHA4FGFR1–phosphorylation
up-regulates activity		22040915SIGNOR-280007
EPHA4STAT5B–phosphorylation
up-regulates activity		28686668SIGNOR-278934
EPHA4EPHA4Tyr596LNQGVRTyVDPFTYEphosphorylation
up-regulates activity		8622893SIGNOR-251118
EPHA4EPHA4Tyr602TYVDPFTyEDPNQAVphosphorylation
up-regulates activity		8622893SIGNOR-251119
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
EPHA4phosphorylation
up-regulates
→
EPHA4
PTyr596		phosphorylation
up-regulates
→		EPHA48622893SIGNOR-251118
EPHA4phosphorylation
up-regulates
→
EPHA4
PTyr602		phosphorylation
up-regulates
→		EPHA48622893SIGNOR-251119
Regulator Mechanism/Effect Target SIGNOR-ID
EPHA4phosphorylation
→
up-regulates activity 		JAK2SIGNOR-279040
EPHA4phosphorylation
→
up-regulates activity 		GHRSIGNOR-279461
EPHA4phosphorylation
→
up-regulates activity 		FGFR1SIGNOR-280007
EPHA4phosphorylation
→
up-regulates activity 		STAT5BSIGNOR-278934
EPHA4phosphorylation
→
up-regulates activity 		EPHA4SIGNOR-251118
EPHA4phosphorylation
→
up-regulates activity 		EPHA4SIGNOR-251119