Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PTPN5	FYN	Tyr420	RLIEDNEyTARQGAK	dephosphorylation down-regulates	11983687	SIGNOR-86791
PTPN5	GRIA2	–		dephosphorylation down-regulates activity	21883219	SIGNOR-277040
PTPN5	GRIN2A	–		dephosphorylation down-regulates activity	27857196	SIGNOR-277089
PTPN5	GRIN2B	Tyr1474	GSSNGHVyEKLSSIE	dephosphorylation down-regulates activity	19625523	SIGNOR-276991
PTPN5	GRIN2B	Tyr1474	GSSNGHVyEKLSSIE	dephosphorylation down-regulates activity	20427654	SIGNOR-265744
PTPN5	BAK1	Tyr108	QPTAENAyEYFTKIA	dephosphorylation up-regulates activity	20959805	SIGNOR-248542
PTPN5	MOB1B	Tyr26	IPEGSHQyELLKHAE	dephosphorylation up-regulates activity	28675297	SIGNOR-277058

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PTPN5	dephosphorylation down-regulates ⊣	FYN PTyr420	dephosphorylation up-regulates →	FYN	11983687	SIGNOR-86791
PTPN5	dephosphorylation down-regulates ⊣	GRIN2B PTyr1474	dephosphorylation up-regulates →	GRIN2B	19625523	SIGNOR-276991
PTPN5	dephosphorylation down-regulates ⊣	GRIN2B PTyr1474	dephosphorylation up-regulates →	GRIN2B	20427654	SIGNOR-265744
PTPN5	dephosphorylation down-regulates ⊣	BAK1 PTyr108	dephosphorylation down-regulates ⊣	BAK1	20959805	SIGNOR-248542
PTPN5	dephosphorylation down-regulates ⊣	MOB1B PTyr26	dephosphorylation down-regulates ⊣	MOB1B	28675297	SIGNOR-277058

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PTPN5	dephosphorylation down-regulates	FYN	SIGNOR-86791
PTPN5	dephosphorylation → down-regulates activity	GRIA2	SIGNOR-277040
PTPN5	dephosphorylation → down-regulates activity	GRIN2A	SIGNOR-277089
PTPN5	dephosphorylation → down-regulates activity	GRIN2B	SIGNOR-276991
PTPN5	dephosphorylation → down-regulates activity	GRIN2B	SIGNOR-265744
PTPN5	dephosphorylation → up-regulates activity	BAK1	SIGNOR-248542
PTPN5	dephosphorylation → up-regulates activity	MOB1B	SIGNOR-277058