| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| OXSR1 | SLC12A2 | Thr212 | TNTYYLRtFGHNTMD | phosphorylation up-regulates | 16669787 | SIGNOR-146521 |
| STK39 | SLC12A2 | – | phosphorylation up-regulates activity | 16990453 | SIGNOR-264642 | |
| WNK3 | SLC12A2 | – | phosphorylation up-regulates activity | 21613606 | SIGNOR-264625 | |
| OXSR1 | SLC12A2 | Thr203 | HQHYYYDtHTNTYYL | phosphorylation up-regulates | 16669787 | SIGNOR-146513 |
| AMPK | SLC12A2 | Ser77 | RPLGPTPsQSRFQVD | phosphorylation down-regulates activity | 24702155 | SIGNOR-276630 |
| OXSR1 | SLC12A2 | Thr207 | YYDTHTNtYYLRTFG | phosphorylation up-regulates | 16669787 | SIGNOR-146517 |
| OXSR1 | SLC12A2 | Thr203 | HQHYYYDtHTNTYYL | phosphorylation up-regulates | 12145304 | SIGNOR-90927 |
| WNK1 | SLC12A2 | Thr1023 | QKKQGKNtIDVWWLF | phosphorylation up-regulates activity | 36318922 | SIGNOR-277859 |
| OXSR1 | SLC12A2 | Thr212 | TNTYYLRtFGHNTMD | phosphorylation up-regulates | 12145304 | SIGNOR-90931 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| OXSR1 | phosphorylation up-regulates → | SLC12A2 PThr212 | phosphorylation up-regulates → | SLC12A2 | 16669787 | SIGNOR-146521 |
| OXSR1 | phosphorylation up-regulates → | SLC12A2 PThr203 | phosphorylation up-regulates → | SLC12A2 | 16669787 | SIGNOR-146513 |
| AMPK | phosphorylation up-regulates → | SLC12A2 PSer77 | phosphorylation down-regulates ⊣ | SLC12A2 | 24702155 | SIGNOR-276630 |
| OXSR1 | phosphorylation up-regulates → | SLC12A2 PThr207 | phosphorylation up-regulates → | SLC12A2 | 16669787 | SIGNOR-146517 |
| OXSR1 | phosphorylation up-regulates → | SLC12A2 PThr203 | phosphorylation up-regulates → | SLC12A2 | 12145304 | SIGNOR-90927 |
| WNK1 | phosphorylation up-regulates → | SLC12A2 PThr1023 | phosphorylation up-regulates → | SLC12A2 | 36318922 | SIGNOR-277859 |
| OXSR1 | phosphorylation up-regulates → | SLC12A2 PThr212 | phosphorylation up-regulates → | SLC12A2 | 12145304 | SIGNOR-90931 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| OXSR1 | phosphorylation → up-regulates | SLC12A2 | SIGNOR-146521 |
| STK39 | phosphorylation → up-regulates activity | SLC12A2 | SIGNOR-264642 |
| WNK3 | phosphorylation → up-regulates activity | SLC12A2 | SIGNOR-264625 |
| OXSR1 | phosphorylation → up-regulates | SLC12A2 | SIGNOR-146513 |
| AMPK | phosphorylation → down-regulates activity | SLC12A2 | SIGNOR-276630 |
| OXSR1 | phosphorylation → up-regulates | SLC12A2 | SIGNOR-146517 |
| OXSR1 | phosphorylation → up-regulates | SLC12A2 | SIGNOR-90927 |
| WNK1 | phosphorylation → up-regulates activity | SLC12A2 | SIGNOR-277859 |
| OXSR1 | phosphorylation → up-regulates | SLC12A2 | SIGNOR-90931 |
