Entity Details

Name SLC12A3
ID P55017
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
STK39SLC12A3Thr55SSTFCMRtFGYNTIDphosphorylation
down-regulates activity		25651566SIGNOR-264623
WNK4SLC12A3Thr50SHLTHSStFCMRTFGphosphorylation
up-regulates activity		22342722SIGNOR-264631
OXSR1SLC12A3Thr60MRTFGYNtIDVVPTYphosphorylation
up-regulates		18270262SIGNOR-160833
WNK3SLC12A3–phosphorylation
up-regulates activity		21613606SIGNOR-264624
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
STK39phosphorylation
up-regulates
→
SLC12A3
PThr55		phosphorylation
down-regulates
⊣		SLC12A325651566SIGNOR-264623
WNK4phosphorylation
up-regulates
→
SLC12A3
PThr50		phosphorylation
up-regulates
→		SLC12A322342722SIGNOR-264631
OXSR1phosphorylation
up-regulates
→
SLC12A3
PThr60		phosphorylation
up-regulates
→		SLC12A318270262SIGNOR-160833
Regulator Mechanism/Effect Target SIGNOR-ID
STK39phosphorylation
→
down-regulates activity 		SLC12A3SIGNOR-264623
WNK4phosphorylation
→
up-regulates activity 		SLC12A3SIGNOR-264631
OXSR1phosphorylation
→
up-regulates 		SLC12A3SIGNOR-160833
WNK3phosphorylation
→
up-regulates activity 		SLC12A3SIGNOR-264624