| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN3 | VCP | Tyr796 | GGTGGSVyTEDNDDD | dephosphorylation down-regulates activity | 10364224 | SIGNOR-248460 |
| AKT1 | VCP | Ser746 | AMRFARRsVSDNDIR | phosphorylation up-regulates | 16551632 | SIGNOR-252492 |
| AKT | VCP | Ser748 | RFARRSVsDNDIRKY | phosphorylation up-regulates | 16551632 | SIGNOR-145292 |
| AKT1 | VCP | Ser352 | AATNRPNsIDPALRR | phosphorylation up-regulates | 16551632 | SIGNOR-252491 |
| PTPN3 | VCP | Tyr805 | EDNDDDLyG | dephosphorylation down-regulates activity | 10364224 | SIGNOR-248461 |
| AKT | VCP | Ser352 | AATNRPNsIDPALRR | phosphorylation up-regulates | 16551632 | SIGNOR-145284 |
| AKT | VCP | Ser746 | AMRFARRsVSDNDIR | phosphorylation up-regulates | 16551632 | SIGNOR-145288 |
| AKT1 | VCP | Ser748 | RFARRSVsDNDIRKY | phosphorylation up-regulates | 16551632 | SIGNOR-252493 |
| PTPRO | VCP | – | dephosphorylation down-regulates activity | 23533167 | SIGNOR-277063 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN3 | dephosphorylation down-regulates ⊣ | VCP PTyr796 | dephosphorylation up-regulates → | VCP | 10364224 | SIGNOR-248460 |
| AKT1 | phosphorylation up-regulates → | VCP PSer746 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-252492 |
| AKT | phosphorylation up-regulates → | VCP PSer748 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-145292 |
| AKT1 | phosphorylation up-regulates → | VCP PSer352 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-252491 |
| PTPN3 | dephosphorylation down-regulates ⊣ | VCP PTyr805 | dephosphorylation up-regulates → | VCP | 10364224 | SIGNOR-248461 |
| AKT | phosphorylation up-regulates → | VCP PSer352 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-145284 |
| AKT | phosphorylation up-regulates → | VCP PSer746 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-145288 |
| AKT1 | phosphorylation up-regulates → | VCP PSer748 | phosphorylation up-regulates → | VCP | 16551632 | SIGNOR-252493 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN3 | dephosphorylation → down-regulates activity | VCP | SIGNOR-248460 |
| AKT1 | phosphorylation → up-regulates | VCP | SIGNOR-252492 |
| AKT | phosphorylation → up-regulates | VCP | SIGNOR-145292 |
| AKT1 | phosphorylation → up-regulates | VCP | SIGNOR-252491 |
| PTPN3 | dephosphorylation → down-regulates activity | VCP | SIGNOR-248461 |
| AKT | phosphorylation → up-regulates | VCP | SIGNOR-145284 |
| AKT | phosphorylation → up-regulates | VCP | SIGNOR-145288 |
| AKT1 | phosphorylation → up-regulates | VCP | SIGNOR-252493 |
| PTPRO | dephosphorylation → down-regulates activity | VCP | SIGNOR-277063 |
