| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | AQP4 | Ser276 | AAQQTKGsYMEVEDN | phosphorylation down-regulates activity | 11742978 | SIGNOR-250974 |
| CSNK2A2 | AQP4 | Ser285 | MEVEDNRsQVETDDL | phosphorylation down-regulates activity | 11742978 | SIGNOR-250975 |
| CSNK2A1 | AQP4 | Ser285 | MEVEDNRsQVETDDL | phosphorylation down-regulates activity | 11742978 | SIGNOR-250827 |
| CSNK2A1 | AQP4 | Ser316 | EKKGKDQsGEVLSSV | phosphorylation down-regulates activity | 11742978 | SIGNOR-250828 |
| CSNK2A1 | AQP4 | Ser276 | AAQQTKGsYMEVEDN | phosphorylation down-regulates activity | 11742978 | SIGNOR-250826 |
| CSNK2A2 | AQP4 | Ser316 | EKKGKDQsGEVLSSV | phosphorylation down-regulates activity | 11742978 | SIGNOR-250976 |
| PKC | AQP4 | Ser180 | TIFASCDsKRTDVTG | phosphorylation down-regulates activity | 19761816 | SIGNOR-276260 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A2 | phosphorylation up-regulates → | AQP4 PSer276 | phosphorylation down-regulates ⊣ | AQP4 | 11742978 | SIGNOR-250974 |
| CSNK2A2 | phosphorylation up-regulates → | AQP4 PSer285 | phosphorylation down-regulates ⊣ | AQP4 | 11742978 | SIGNOR-250975 |
| CSNK2A1 | phosphorylation up-regulates → | AQP4 PSer285 | phosphorylation down-regulates ⊣ | AQP4 | 11742978 | SIGNOR-250827 |
| CSNK2A1 | phosphorylation up-regulates → | AQP4 PSer316 | phosphorylation down-regulates ⊣ | AQP4 | 11742978 | SIGNOR-250828 |
| CSNK2A1 | phosphorylation up-regulates → | AQP4 PSer276 | phosphorylation down-regulates ⊣ | AQP4 | 11742978 | SIGNOR-250826 |
| CSNK2A2 | phosphorylation up-regulates → | AQP4 PSer316 | phosphorylation down-regulates ⊣ | AQP4 | 11742978 | SIGNOR-250976 |
| PKC | phosphorylation up-regulates → | AQP4 PSer180 | phosphorylation down-regulates ⊣ | AQP4 | 19761816 | SIGNOR-276260 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A2 | phosphorylation → down-regulates activity | AQP4 | SIGNOR-250974 |
| CSNK2A2 | phosphorylation → down-regulates activity | AQP4 | SIGNOR-250975 |
| CSNK2A1 | phosphorylation → down-regulates activity | AQP4 | SIGNOR-250827 |
| CSNK2A1 | phosphorylation → down-regulates activity | AQP4 | SIGNOR-250828 |
| CSNK2A1 | phosphorylation → down-regulates activity | AQP4 | SIGNOR-250826 |
| CSNK2A2 | phosphorylation → down-regulates activity | AQP4 | SIGNOR-250976 |
| PKC | phosphorylation → down-regulates activity | AQP4 | SIGNOR-276260 |
