| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | CASP7 | Ser239 | WRSPGRGsWFVQALC | phosphorylation down-regulates | 21555521 | SIGNOR-173655 |
| PAK2 | CASP7 | Thr173 | FRGDRCKtLLEKPKL | phosphorylation down-regulates | 21555521 | SIGNOR-173663 |
| PAK2 | CASP7 | Ser30 | DAKPDRSsFVPSLFS | phosphorylation down-regulates | 21555521 | SIGNOR-173659 |
| SRC | CASP7 | – | phosphorylation up-regulates activity | 24407236 | SIGNOR-278455 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK2 | phosphorylation up-regulates → | CASP7 PSer239 | phosphorylation down-regulates ⊣ | CASP7 | 21555521 | SIGNOR-173655 |
| PAK2 | phosphorylation up-regulates → | CASP7 PThr173 | phosphorylation down-regulates ⊣ | CASP7 | 21555521 | SIGNOR-173663 |
| PAK2 | phosphorylation up-regulates → | CASP7 PSer30 | phosphorylation down-regulates ⊣ | CASP7 | 21555521 | SIGNOR-173659 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK2 | phosphorylation down-regulates | CASP7 | SIGNOR-173655 |
| PAK2 | phosphorylation down-regulates | CASP7 | SIGNOR-173663 |
| PAK2 | phosphorylation down-regulates | CASP7 | SIGNOR-173659 |
| SRC | phosphorylation → up-regulates activity | CASP7 | SIGNOR-278455 |
