| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | ADAR | Thr1033 | RLGERLRtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-266357 |
| AKT3 | ADAR | Thr1033 | RLGERLRtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-276191 |
| AKT1 | ADAR | Thr1033 | RLGERLRtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-276193 |
| AKT2 | ADAR | Thr1033 | RLGERLRtMSCSDKI | phosphorylation down-regulates activity | 31095429 | SIGNOR-276192 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | ADAR PThr1033 | phosphorylation down-regulates ⊣ | ADAR | 31095429 | SIGNOR-266357 |
| AKT3 | phosphorylation up-regulates → | ADAR PThr1033 | phosphorylation down-regulates ⊣ | ADAR | 31095429 | SIGNOR-276191 |
| AKT1 | phosphorylation up-regulates → | ADAR PThr1033 | phosphorylation down-regulates ⊣ | ADAR | 31095429 | SIGNOR-276193 |
| AKT2 | phosphorylation up-regulates → | ADAR PThr1033 | phosphorylation down-regulates ⊣ | ADAR | 31095429 | SIGNOR-276192 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | ADAR | SIGNOR-266357 |
| AKT3 | phosphorylation → down-regulates activity | ADAR | SIGNOR-276191 |
| AKT1 | phosphorylation → down-regulates activity | ADAR | SIGNOR-276193 |
| AKT2 | phosphorylation → down-regulates activity | ADAR | SIGNOR-276192 |