| Name | MARS1 |
| ID | P56192 |
| Role | substrate |
| Enzymatic Domains |
GST C-terminal 74-198
WHEP-TRS 841-897 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | MARS1 | Ser825 | GGGQAKTsPKPAVVE | phosphorylation up-regulates activity | 25097229 | SIGNOR-277833 |
| ERK1/2 | MARS1 | Ser825 | GGGQAKTsPKPAVVE | phosphorylation up-regulates activity | 25097229 | SIGNOR-276670 |
| EIF2AK4 | MARS1 | Ser662 | NRAGMFVsKFFGGYV | phosphorylation down-regulates | 22106287 | SIGNOR-177648 |
| ERK1/2 | MARS1 | Ser209 | LQKQPQPsPAEGRAV | phosphorylation up-regulates activity | 25097229 | SIGNOR-276671 |
| ERK1/2 | MARS1 | Ser209 | LQKQPQPsPAEGRAV | phosphorylation up-regulates activity | 25097229 | SIGNOR-277834 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer825 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-277833 |
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer825 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-276670 |
| EIF2AK4 | phosphorylation up-regulates → | MARS1 PSer662 | phosphorylation down-regulates ⊣ | MARS1 | 22106287 | SIGNOR-177648 |
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer209 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-276671 |
| ERK1/2 | phosphorylation up-regulates → | MARS1 PSer209 | phosphorylation up-regulates → | MARS1 | 25097229 | SIGNOR-277834 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-277833 |
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-276670 |
| EIF2AK4 | phosphorylation down-regulates | MARS1 | SIGNOR-177648 |
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-276671 |
| ERK1/2 | phosphorylation → up-regulates activity | MARS1 | SIGNOR-277834 |