| Name | BCAR1 |
| ID | P56945 |
| Role | substrate |
| Enzymatic Domains |
SH3 3-65 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2B | BCAR1 | – | phosphorylation up-regulates activity | 15263022 | SIGNOR-280100 | |
| FGFR1 | BCAR1 | Tyr410 | GVVDSGVyAVPPPAE | phosphorylation up-regulates | 12601080 | SIGNOR-98569 |
| PTK2 | BCAR1 | Tyr664 | EGGWMEDyDYVHLQG | phosphorylation unknown | 11604500 | SIGNOR-249111 |
| FYN | BCAR1 | – | phosphorylation up-regulates activity | 24586768 | SIGNOR-279372 | |
| FGFR1 | BCAR1 | Tyr327 | PLLREETyDVPPAFA | phosphorylation up-regulates | 12601080 | SIGNOR-98500 |
| SRC | BCAR1 | Tyr362 | SPPAEDVyDVPPPAP | phosphorylation up-regulates activity | 12972425 | SIGNOR-246409 |
| PTPRF | BCAR1 | – | dephosphorylation down-regulates quantity by destabilization | 10320483 | SIGNOR-276998 | |
| PTK6 | BCAR1 | Tyr165 | PSPATDLyQVPPGPG | phosphorylation up-regulates activity | 22084245 | SIGNOR-177238 |
| SRC | BCAR1 | Tyr115 | QPQPDSVyLVPTPSK | phosphorylation up-regulates activity | 12972425 | SIGNOR-246381 |
| FGFR1 | BCAR1 | Tyr306 | PSNHHAVyDVPPSVS | phosphorylation up-regulates | 12601080 | SIGNOR-98496 |
| BMX | BCAR1 | Tyr12 | NVLAKALyDNVAESP | phosphorylation up-regulates quantity | 21937722 | SIGNOR-276384 |
| SRC | BCAR1 | Tyr666 | GWMEDYDyVHLQGKE | phosphorylation up-regulates activity | 11604500 | SIGNOR-111060 |
| SRC | BCAR1 | Tyr234 | AQPEQDEyDIPRHLL | phosphorylation up-regulates activity | 12972425 | SIGNOR-246397 |
| SRC | BCAR1 | Tyr249 | APGPQDIyDVPPVRG | phosphorylation up-regulates activity | 12972425 | SIGNOR-100363 |
| SRC | BCAR1 | Tyr387 | RPGPGTLyDVPRERV | phosphorylation up-regulates activity | 12972425 | SIGNOR-246413 |
| SRC | BCAR1 | Tyr192 | AGMGHDIyQVPPSMD | phosphorylation up-regulates activity | 12972425 | SIGNOR-246393 |
| PTK2 | BCAR1 | Tyr666 | GWMEDYDyVHLQGKE | phosphorylation unknown | 11604500 | SIGNOR-249112 |
| SRC | BCAR1 | Tyr179 | GGPAQDIyQVPPSAG | phosphorylation up-regulates activity | 12972425 | SIGNOR-246389 |
| SRC | BCAR1 | Tyr664 | EGGWMEDyDYVHLQG | phosphorylation up-regulates activity | 11604500 | SIGNOR-111056 |
| SRC | BCAR1 | Tyr653 | QDSPDGQyENSEGGW | phosphorylation up-regulates activity | 12972425 | SIGNOR-246417 |
| SRC | BCAR1 | Tyr128 | SKAQQGLyQVPGPSP | phosphorylation up-regulates activity | 22710723 | SIGNOR-197927 |
| PTPN12 | BCAR1 | – | dephosphorylation down-regulates | 11432829 | SIGNOR-109032 | |
| PTPN14 | BCAR1 | Tyr128 | SKAQQGLyQVPGPSP | dephosphorylation down-regulates | 22710723 | SIGNOR-197923 |
| SRC | BCAR1 | Tyr267 | SQYGQEVyDTPPMAV | phosphorylation up-regulates activity | 12972425 | SIGNOR-246401 |
| ABL1 | BCAR1 | – | phosphorylation up-regulates activity | 17615370 | SIGNOR-279671 | |
| SRC | BCAR1 | Tyr287 | RDPLLEVyDVPPSVE | phosphorylation up-regulates activity | 12972425 | SIGNOR-246405 |
| SRC | BCAR1 | Tyr165 | PSPATDLyQVPPGPG | phosphorylation up-regulates activity | 12972425 | SIGNOR-246385 |
| PTK6 | BCAR1 | Tyr664 | EGGWMEDyDYVHLQG | phosphorylation up-regulates | 22084245 | SIGNOR-177242 |
| PKN3 | BCAR1 | Ser428 | PAEGKRLsASSTGST | phosphorylation unknown | 30422386 | SIGNOR-264574 |
| FGFR1 | BCAR1 | Tyr128 | SKAQQGLyQVPGPSP | phosphorylation up-regulates | 11019781 | SIGNOR-82760 |
| FGFR1 | BCAR1 | Tyr128 | SKAQQGLyQVPGPSP | phosphorylation up-regulates | 12601080 | SIGNOR-98488 |
| FGFR1 | BCAR1 | Tyr249 | APGPQDIyDVPPVRG | phosphorylation up-regulates | 12601080 | SIGNOR-98492 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr410 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98569 |
| PTK2 | phosphorylation up-regulates → | BCAR1 PTyr664 | phosphorylation down-regulates ⊣ | BCAR1 | 11604500 | SIGNOR-249111 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr327 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98500 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr362 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246409 |
| PTK6 | phosphorylation up-regulates → | BCAR1 PTyr165 | phosphorylation up-regulates → | BCAR1 | 22084245 | SIGNOR-177238 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr115 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246381 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr306 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98496 |
| BMX | phosphorylation up-regulates → | BCAR1 PTyr12 | phosphorylation up-regulates → | BCAR1 | 21937722 | SIGNOR-276384 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr666 | phosphorylation up-regulates → | BCAR1 | 11604500 | SIGNOR-111060 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr234 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246397 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr249 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-100363 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr387 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246413 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr192 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246393 |
| PTK2 | phosphorylation up-regulates → | BCAR1 PTyr666 | phosphorylation down-regulates ⊣ | BCAR1 | 11604500 | SIGNOR-249112 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr179 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246389 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr664 | phosphorylation up-regulates → | BCAR1 | 11604500 | SIGNOR-111056 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr653 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246417 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr128 | phosphorylation up-regulates → | BCAR1 | 22710723 | SIGNOR-197927 |
| PTPN14 | dephosphorylation down-regulates ⊣ | BCAR1 PTyr128 | dephosphorylation up-regulates → | BCAR1 | 22710723 | SIGNOR-197923 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr267 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246401 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr287 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246405 |
| SRC | phosphorylation up-regulates → | BCAR1 PTyr165 | phosphorylation up-regulates → | BCAR1 | 12972425 | SIGNOR-246385 |
| PTK6 | phosphorylation up-regulates → | BCAR1 PTyr664 | phosphorylation up-regulates → | BCAR1 | 22084245 | SIGNOR-177242 |
| PKN3 | phosphorylation up-regulates → | BCAR1 PSer428 | phosphorylation down-regulates ⊣ | BCAR1 | 30422386 | SIGNOR-264574 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr128 | phosphorylation up-regulates → | BCAR1 | 11019781 | SIGNOR-82760 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr128 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98488 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr249 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98492 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2B | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-280100 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98569 |
| PTK2 | phosphorylation → unknown | BCAR1 | SIGNOR-249111 |
| FYN | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-279372 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98500 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246409 |
| PTPRF | dephosphorylation down-regulates quantity by destabilization | BCAR1 | SIGNOR-276998 |
| PTK6 | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-177238 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246381 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98496 |
| BMX | phosphorylation → up-regulates quantity | BCAR1 | SIGNOR-276384 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-111060 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246397 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-100363 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246413 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246393 |
| PTK2 | phosphorylation → unknown | BCAR1 | SIGNOR-249112 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246389 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-111056 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246417 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-197927 |
| PTPN12 | dephosphorylation down-regulates | BCAR1 | SIGNOR-109032 |
| PTPN14 | dephosphorylation down-regulates | BCAR1 | SIGNOR-197923 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246401 |
| ABL1 | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-279671 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246405 |
| SRC | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-246385 |
| PTK6 | phosphorylation → up-regulates | BCAR1 | SIGNOR-177242 |
| PKN3 | phosphorylation → unknown | BCAR1 | SIGNOR-264574 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-82760 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98488 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98492 |